All Phenotypes Erbb2<tm1Vrtn> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Erbb2^tm1Vrtn
targeted mutation 1, Timothy Vartanian
MGI:2651799

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb2^tm1Vrtn/Erbb2^tm1Vrtn	Not Specified	MGI:2651800

Allelic Composition	Erbb2^tm1Vrtn/Erbb2^tm1Vrtn
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Vrtn mutation (0 available); any Erbb2 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:71775 )

• embryos fail to develop past E11.5

nervous system

abnormal oligodendrocyte morphology ( J:71775 )

• oligodendrocyte development is arrested at the proligodendroblast stage in spinal cord explants from E9.5 embryos, with a greater than 10-fold reduction in the number of galactosylcerebroside-positive oligodendroctyes

• of the oligodendrocytes that do differentiate, all fail to ensheath neurites

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24