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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mertknmf12
neuroscience mutagenesis facility, 12
MGI:2651819
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mertknmf12/Mertknmf12 C57BL/6J-Mertknmf12/J MGI:2651860
hm2
 		Mertknmf12/Mertknmf12 involves: C57BL/6J MGI:5287878
ht3
 		Mertknmf12/Mertktm1Gkm involves: 129P2/OlaHsd * C57BL/6J MGI:5287879
cx4
 		Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Mertknmf12/Mertknmf12 		involves: C57BL/6J MGI:5287880
cx5
 		Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Mertknmf12/Mertknmf12 		involves: C57BL/6J MGI:5287881
cx6
 		Mertknmf12/Mertknmf12
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk 		involves: C57BL/6J MGI:5287882


Genotype
MGI:2651860
hm1
Allelic
Composition		 Mertknmf12/Mertknmf12
Genetic
Background		 C57BL/6J-Mertknmf12/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mertknmf12 mutation (1 available); any Mertk mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina morphology ( J:82238 )
• the peripheral retina is described as thin with white intraretinal patches




Genotype
MGI:5287878
hm2
Allelic
Composition		 Mertknmf12/Mertknmf12
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mertknmf12 mutation (1 available); any Mertk mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
increased retina apoptosis ( J:175587 )
• photoreceptor apoptosis is seen throughout the retina at P45
• however, most photoreceptors in the central retina are spared
abnormal retina pigmentation ( J:175587 )
• loss of pigmentation in the peripheral retina as early as P30
• depigmented patches develop in the central retina with age
thin retina outer nuclear layer ( J:175587 )
• peripheral thinning at P30 that progresses with age
abnormal retina photoreceptor layer morphology ( J:175587 )
• a single layer of photoreceptor nuclei is left adjacent to the retinal pigment epithelium in the peripheral retina at 6 months of age
decreased retina photoreceptor cell number ( J:175587 )
• photoreceptor cell death increases with age
abnormal eye electrophysiology ( J:175587 )
• electroretinographic recordings become progressively attenuated with age but remain detectable at 2 years of age

homeostasis/metabolism
abnormal tumor necrosis factor level ( J:175587 )
• elevated TNF levels in the retina

immune system
abnormal tumor necrosis factor level ( J:175587 )
• elevated TNF levels in the retina

nervous system
decreased retina photoreceptor cell number ( J:175587 )
• photoreceptor cell death increases with age

pigmentation
abnormal retina pigmentation ( J:175587 )
• loss of pigmentation in the peripheral retina as early as P30
• depigmented patches develop in the central retina with age

cellular
increased retina apoptosis ( J:175587 )
• photoreceptor apoptosis is seen throughout the retina at P45
• however, most photoreceptors in the central retina are spared




Genotype
MGI:5287879
ht3
Allelic
Composition		 Mertknmf12/Mertktm1Gkm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mertknmf12 mutation (1 available); any Mertk mutation (65 available)
Mertktm1Gkm mutation (0 available); any Mertk mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina morphology ( J:175587 )
• pan-retinal fundus patches
decreased retina photoreceptor cell number ( J:175587 )
• severe photoreceptor loss in the peripheral retina

nervous system
decreased retina photoreceptor cell number ( J:175587 )
• severe photoreceptor loss in the peripheral retina




Genotype
MGI:5287880
cx4
Allelic
Composition		 Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Mertknmf12/Mertknmf12
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Ltatm1Dvk mutation (1 available); any Ltb mutation (19 available)
Mertknmf12 mutation (1 available); any Mertk mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina morphology ( J:175587 )
• at P45 abnormalities are seen across the entire retina
retina photoreceptor degeneration ( J:175587 )
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone
thin retina inner nuclear layer ( J:175587 )
• in the peripheral retina at 3 months of age
thin retina outer nuclear layer ( J:175587 )
• markedly thinned across the entire retina at 3 months of age

nervous system
retina photoreceptor degeneration ( J:175587 )
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone




Genotype
MGI:5287881
cx5
Allelic
Composition		 Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Mertknmf12/Mertknmf12
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Ltatm1Dvk mutation (1 available); any Lta mutation (17 available)
Mertknmf12 mutation (1 available); any Mertk mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina morphology ( J:175587 )
• at P45 abnormalities are seen across the entire retina
retina photoreceptor degeneration ( J:175587 )
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone
thin retina inner nuclear layer ( J:175587 )
• in the peripheral retina at 3 months of age
thin retina outer nuclear layer ( J:175587 )
• markedly thinned across the entire retina at 3 months of age

nervous system
retina photoreceptor degeneration ( J:175587 )
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone




Genotype
MGI:5287882
cx6
Allelic
Composition		 Mertknmf12/Mertknmf12
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Ltatm1Dvk mutation (1 available); any Tnf mutation (48 available)
Mertknmf12 mutation (1 available); any Mertk mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina morphology ( J:175587 )
• at P45 abnormalities are seen across the entire retina
retina photoreceptor degeneration ( J:175587 )
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone
thin retina inner nuclear layer ( J:175587 )
• in the peripheral retina at 3 months of age
thin retina outer nuclear layer ( J:175587 )
• markedly thinned across the entire retina at 3 months of age

nervous system
retina photoreceptor degeneration ( J:175587 )
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory