Phenotypes associated with this allele

• Allele Symbol: nmf67
• Allele Name: neuroscience mutagenesis facility, 67
• Allele ID: MGI:2651831
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	nmf67/nmf67	C57BL/6J-nmf67/J	MGI:2651878

Genotype
MGI:2651878

hm1

• Allelic Composition: nmf67/nmf67
• Genetic Background: C57BL/6J-nmf67/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:82238 )

• at approximately 4 weeks of age

behavior/neurological

abnormal gait ( J:82238 )

• apparent by 3 weeks of age

muscle

muscle weakness ( J:82238 )

• apparent by 3 weeks of age

vision/eye

abnormal retina morphology ( J:82238 )

disorganized retina layers ( J:82238 )

• multi-focal abnormalities; nuclei of the outer nuclear layer were displaced into the photoreceptor layer

nervous system

brain vacuoles ( J:82238 )

• white matter of the medulla and cerebellum was severely vacuolated in mice ranging from 23-30 days in age

abnormal neuromuscular synapse morphology ( J:82238 )

• abnormal formation; the post-synaptic acetylcholine receptors appeared broken up and have not resolved into a smooth continuous shape

abnormal spinal cord white matter morphology ( J:82238 )

• white matter of the spinal cord was severely vacuolated in mice ranging from 23-30 days in age