Phenotypes associated with this allele

• Allele Symbol: Ldb3^tm3Chen
• Allele Name: targeted mutation 3, Ju Chen
• Allele ID: MGI:2652078
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ldb3^tm3Chen/Ldb3^tm3Chen	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:2652082

Genotype
MGI:2652082

hm1

• Allelic Composition: Ldb3^tm3Chen/Ldb3^tm3Chen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skeletal muscle abnormalities in Ldb3^tm2Chen/Ldb3^tm2Chen and Ldb3^tm3Chen/Ldb3^tm3Chen mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:82141 )

• approximately 80% died within the first 4 weeks; the rest survived to adulthood

cardiovascular system

cardiac fibrosis ( J:82141 )

• fibrosis observed in cardiac muscle

growth/size/body

decreased body weight ( J:82141 )

• 40% weight reduction relative to controls

muscle

abnormal skeletal muscle morphology ( J:82141 )

skeletal muscle fiber atrophy ( J:82141 )

• skeletal muscle fibers show numerous atrophic fibers

increased variability of skeletal muscle fiber size ( J:82141 )

• skeletal muscle fibers show variation in myofiber size

myopathy ( J:82141 )

• muscle abnormalities were more severe than in Ldb3^tm2Chen