Phenotypes associated with this allele

• Allele Symbol: H2-DMa^tm1Lkrl
• Allele Name: targeted mutation 1, Lars Karlsson
• Allele ID: MGI:2652160
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-DMa^tm1Lkrl/H2-DMa^tm1Lkrl	involves: 129P2/OlaHsd	MGI:2652161

Genotype
MGI:2652161

hm1

• Allelic Composition: H2-DMa^tm1Lkrl/H2-DMa^tm1Lkrl
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal positive T cell selection ( J:31786 )

• positive selection of CD4+ T cells occurs at reduced levels

decreased CD4-positive, alpha-beta T cell number ( J:31786 )

• proportion of lymph node and splenic CD4+ cells is reduced to about 30-50% of that in control mice

• reduction of CD4+ cells in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:31786 )

• CD4+ cells are unresponsive to their own antigen-presenting cells (APCs) but are hyperreactive to wild-type APCs

• CD4+ cells are 10- to 100-fold more responsive to H2-A^b than wild-type cells

abnormal professional antigen presenting cell physiology ( J:31786 )

• antigen presenting cells (APCs) have defective protein and peptide presentation

• APCs fail to stimulate MHC allogeneic T cells

abnormal antigen presentation ( J:31786 )

hematopoietic system

abnormal positive T cell selection ( J:31786 )

• positive selection of CD4+ T cells occurs at reduced levels

decreased CD4-positive, alpha-beta T cell number ( J:31786 )

• proportion of lymph node and splenic CD4+ cells is reduced to about 30-50% of that in control mice

• reduction of CD4+ cells in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:31786 )

• CD4+ cells are unresponsive to their own antigen-presenting cells (APCs) but are hyperreactive to wild-type APCs

• CD4+ cells are 10- to 100-fold more responsive to H2-A^b than wild-type cells