Phenotypes associated with this allele

• Allele Symbol: Hes7^tm1Kag
• Allele Name: targeted mutation 1, Ryoichiro Kageyama
• Allele ID: MGI:2652222
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hes7^tm1Kag/Hes7^tm1Kag	involves: ICR	MGI:2655697
hm2	Hes7^tm1Kag/Hes7^tm1Kag	Not Specified	MGI:3046539
ht3	Hes7^tm1Kag/Hes7^+	involves: ICR	MGI:2664934
ht4	Hes7^tm1Kag/Hes7^+	Not Specified	MGI:5431507
ht5	Hes7^tm1Kag/Hes7^tm2.1Dihz	involves: 129 * C57BL/6J	MGI:5426222

Genotype
MGI:2655697

hm1

• Allelic Composition: Hes7^tm1Kag/Hes7^tm1Kag
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:72325 )

• most died within a few hours of birth, apparently from respiratory failure

embryo

abnormal somite development ( J:72325 )

abnormal left-right axis symmetry of the somites ( J:72325 )

• loss of left-right axis somite symmetry

abnormal dorsal-ventral polarity of the somites ( J:72325 )

• disrupted anterior-posterior polarity of the somites

abnormal somite shape ( J:72325 )

• somites were irregular in both size and shape, and the boundaries between somites were less clear

abnormal somite size ( J:72325 )

• somites were irregular in both size and shape, and the boundaries between somites were less clear

incomplete somite formation ( J:72325 )

• abnormal segmentation

growth/size/body

decreased body length ( J:72325 )

limbs/digits/tail

short tail ( J:72325 )

skeleton

decreased rib number ( J:72325 )

• 8 to 9 pairs of ribs (normally 13)

rib bifurcation ( J:72325 )

rib fusion ( J:72325 )

abnormal vertebrae morphology ( J:72325 )

• segmentation defects

abnormal intervertebral disk development ( J:72325 )

• defective patterning of intervertebral disks

abnormal vertebral arch morphology ( J:72325 )

• malformation of neural arches

fusion of vertebral arches ( J:72325 )

abnormal vertebral body morphology ( J:72325 )

• malformation of vertebral bodies

abnormal vertebral body development ( J:72325 )

• defective patterning of vertebral bodies

fusion of vertebral bodies ( J:72325 )

Genotype
MGI:3046539

hm2

• Allelic Composition: Hes7^tm1Kag/Hes7^tm1Kag
• Genetic Background: Not Specified

Irregular sacral segmentation in Hes7^tm1Kag/Hes7^tm1Kag mice

embryo

fused somites ( J:91127 )

• somites are fused throughout the entire anterior-posterior axis

skeleton

abnormal sacral vertebrae morphology ( J:155378 )

• fail to form regular sacral vertebrae

Genotype
MGI:2664934

ht3

• Allelic Composition: Hes7^tm1Kag/Hes7⁺
• Genetic Background: involves: ICR

limbs/digits/tail

kinked tail ( J:72325 )

Genotype
MGI:5431507

ht4

• Allelic Composition: Hes7^tm1Kag/Hes7⁺
• Genetic Background: Not Specified

skeleton

abnormal vertebrae morphology ( J:186213 )

• predominantly in vertebrae T7 to L4 in 16 of 30 mice at E14.5

Genotype
MGI:5426222

ht5

• Allelic Composition: Hes7^tm1Kag/Hes7^tm2.1Dihz
• Genetic Background: involves: 129 * C57BL/6J

skeleton

abnormal skeleton morphology ( J:184024 )

• disorganized at E18.5

abnormal rib morphology ( J:184024 )

• extensive and severe malformations at E18.5

rib fusion ( J:184024 )

• at E18.5

abnormal vertebral column morphology ( J:184024 )

• at E18.5, mice lack regular vertebrae

abnormal vertebrae morphology ( J:184024 )

• extensive and severe malformations at E18.5

abnormal sacral vertebrae morphology ( J:184024 )

• at E18.5

vertebral fusion ( J:184024 )

• at E18.5

limbs/digits/tail

short tail ( J:184024 )

• at E18.5