All Phenotypes App<tm1.1Cep> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

App^tm1.1Cep
targeted mutation 1.1, Cephalon
MGI:2652346

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	App^tm1.1Cep/App^tm1.1Cep	involves: 129S1/Sv * 129X1/SvJ	MGI:2652362
ht2	App^tm1.1Cep/App⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2652363
cx3	App^tm1.1Cep/App^tm1.1Cep Psen1^tm1Dgf/Psen1^tm1Dgf	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3611210

Allelic Composition	App^tm1.1Cep/App^tm1.1Cep
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1.1Cep mutation (0 available); any App mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:35500 )

• increased amyloidogenic processing of App

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:35500

Allelic Composition	App^tm1.1Cep/App⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1.1Cep mutation (0 available); any App mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:35500 )

• increased amyloidogenic processing of App

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:35500

Allelic Composition	App^tm1.1Cep/App^tm1.1Cep Psen1^tm1Dgf/Psen1^tm1Dgf
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1.1Cep mutation (0 available); any App mutation (105 available)
Psen1^tm1Dgf mutation (0 available); any Psen1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:66147 , J:102425 )

• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)

• amyloid-beta deposition beginning at 6 months of age (J:102425)

• deposition increased linearly over time (J:102425)

homeostasis/metabolism

amyloid beta deposits ( J:66147 , J:102425 )

• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)

• amyloid-beta deposition beginning at 6 months of age (J:102425)

• deposition increased linearly over time (J:102425)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:102425

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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