Phenotypes associated with this allele

• Allele Symbol: Sod3^tm1Mrkl
• Allele Name: targeted mutation 1, Stefan L Marklund
• Allele ID: MGI:2652386
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sod3^tm1Mrkl/Sod3^tm1Mrkl	D1.129P2-Sod3^tm1Mrkl	MGI:3622560
hm2	Sod3^tm1Mrkl/Sod3^tm1Mrkl	involves: 129P2/OlaHsd * C57BL/6	MGI:2652387

Genotype
MGI:3622560

hm1

• Allelic Composition: Sod3^tm1Mrkl/Sod3^tm1Mrkl
• Genetic Background: D1.129P2-Sod3^tm1Mrkl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased tumor necrosis factor secretion ( J:106273 )

• in culture, LPS-stimulated spleen cells from null mice produce greater levels of TNF than wild-type control cells

autoimmune arthritis ( J:106273 )

• on day 53, the joints of null animals have a 2.2 fold greater mean inflammation score than wild-type, with a pannus score 2.4 fold higher, the cartilage damage score 2.3 fold greater and the bone damage score 2.3 fold greater

increased susceptibility to induced arthritis ( J:106273 )

• after immunization with collagen II on day 21, clinical disease activity score is higher in knockouts by between days 36 and 53 after the initial injection compared with wild-type

skeleton

autoimmune arthritis ( J:106273 )

• on day 53, the joints of null animals have a 2.2 fold greater mean inflammation score than wild-type, with a pannus score 2.4 fold higher, the cartilage damage score 2.3 fold greater and the bone damage score 2.3 fold greater

increased susceptibility to induced arthritis ( J:106273 )

• after immunization with collagen II on day 21, clinical disease activity score is higher in knockouts by between days 36 and 53 after the initial injection compared with wild-type

Genotype
MGI:2652387

hm2

• Allelic Composition: Sod3^tm1Mrkl/Sod3^tm1Mrkl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:26851 )

• when stressed by exposure to hyperoxia (>99% oxygen), mice exhibit significantly reduced survival relative to wild-type controls

homeostasis/metabolism

increased susceptibility to injury ( J:26851 )

• after exposure to hyperoxia (>99% oxygen for 70 hrs), mice exhibit significantly more severe lung edema than wild-type controls

• however, mice develop normally and remain healthy until at least 14 months of age when placed under normal physiological conditions; no compensatory induction of other SOD isoenzymes or other antioxidant enzymes is observed