Phenotypes associated with this allele

• Allele Symbol: Plcb1^tm1Hssh
• Allele Name: targeted mutation 1, Hee-Sup Shin
• Allele ID: MGI:2652485
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plcb1^tm1Hssh/Plcb1^tm1Hssh	involves: 129 * C57BL/6J	MGI:4821148
hm2	Plcb1^tm1Hssh/Plcb1^tm1Hssh	involves: 129/Sv * C57BL/6	MGI:4353812
hm3	Plcb1^tm1Hssh/Plcb1^tm1Hssh	Not Specified	MGI:2652553

Genotype
MGI:4821148

hm1

• Allelic Composition: Plcb1^tm1Hssh/Plcb1^tm1Hssh
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal excitatory postsynaptic currents ( J:159855 )

• CCK-8-treated mice fail to exhibit a change in AMPA excitatory postsynaptic currents unlike in similarly treated wild-type mice

Genotype
MGI:4353812

hm2

• Allelic Composition: Plcb1^tm1Hssh/Plcb1^tm1Hssh
• Genetic Background: involves: 129/Sv * C57BL/6

behavior/neurological

abnormal spatial learning ( J:151070 )

• in a Morris water maze, standard housed and environmentally enriched mice fail to exhibit a preference for the target quadrant unlike similarly treated wild-type mice

• in a Morris water maze, standard housed exhibit decreased frequency of crossing over the platform and increased latency compared with wild-type mice

decreased startle reflex ( J:151070 )

• mice in standard housing exhibit decreased startle reflex compared with wild-type mice in standard housing

• environmental enrichment fails to decrease startle reflex as in similarly treated wild-type mice

• however, clozapine attenuates startle reflex as in wild-type mice

hyperactivity ( J:151070 )

• mice in standard housing exhibit hyperactivity compared with wild-type mice in standard housing

• however, mice exposed to environmental enrichment exhibit normal activity levels

nervous system

decreased prepulse inhibition ( J:151070 )

• mice in standard housing exhibit decreased prepulse inhibition compared with wild-type mice in standard housing

• however, environmental enrichment or treatment with clozapine rescue prepulse inhibition deficit

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:151070

Genotype
MGI:2652553

hm3

• Allelic Composition: Plcb1^tm1Hssh/Plcb1^tm1Hssh
• Genetic Background: Not Specified

mortality/aging

lethality at weaning, incomplete penetrance ( J:43077 )

• most mice died at the age of 3 weeks

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:43077 )

• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)

convulsive seizures ( J:43077 )

• exhibited prior to 3 wks of age

• tonic-clonic or tonic extension of the whole body

• putatively evoked by hippocampal hyperexcitability

growth/size/body

decreased body size ( J:43077 )

nervous system

increased susceptibility to pharmacologically induced seizures ( J:43077 )

• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)

convulsive seizures ( J:43077 )

• exhibited prior to 3 wks of age

• tonic-clonic or tonic extension of the whole body

• putatively evoked by hippocampal hyperexcitability

loss of hippocampal neurons ( J:43077 )

• loss of somatostatin-containing neurons, putatively resulting in hippocampal hyperexcitability leading to seizures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:43077