Phenotypes associated with this allele

• Allele Symbol: Plcb4^tm1Hssh
• Allele Name: targeted mutation 1, Hee-Sup Shin
• Allele ID: MGI:2652541
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plcb4^tm1Hssh/Plcb4^tm1Hssh	Not Specified	MGI:2652554

Genotype
MGI:2652554

hm1

• Allelic Composition: Plcb4^tm1Hssh/Plcb4^tm1Hssh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:43077 )

• mice survived in the absence of normal littermates, indicating a reduced ability to compete with normal littermates

behavior/neurological

ataxia ( J:43077 )

abnormal gait ( J:43077 )

• characterized by a swinging of the rear body, waddling; not attributable to abnormal bone structure or reduced muscle strength

decreased locomotor activity ( J:43077 )

growth/size/body

decreased body size ( J:43077 )

• mice grew normally in the absence of normal littermates, indicating a reduced ability to compete with normal littermates

muscle

muscle phenotype ( J:43077 )

N • demonstrated normal muscle strength in hanging test

skeleton

skeleton phenotype ( J:43077 )

N • normal bone structure

nervous system

abnormal cerebellar foliation ( J:43077 )

• abberant patterns at 15 days of age

abnormal cerebellum external granule cell layer morphology ( J:43077 )

• incomplete migration at 15 days of age, but normal by 50 days of age

small cerebellum ( J:43077 )

• retarded development resulting in a slight size reduction at 50 days of age

abnormal synaptic transmission ( J:43077 )

• impaired metabotropic glutamate receptor signaling in the cerebrum