All Phenotypes Ikbkb<tm2Cgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ikbkb^tm2Cgn
targeted mutation 2, University of Cologne
MGI:2652651

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19⁺ Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:3851694
cn2	Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:2679030
cn3	Ikbkb^tm2Cgn/Ikbkb^tm2Cgn Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:4452486
cn4	Ikbkb^tm2Cgn/Ikbkb^tm2Cgn Tg(Alb1-cre)7Gsc/0	involves: C57BL/6 * FVB/N	MGI:3700374
cn5	Chuk^tm1Mpa/Chuk^tm1Mpa Ikbkb^tm2Cgn/Ikbkb^tm2Cgn Tg(Alb1-cre)7Gsc/0	involves: C57BL/6 * FVB/N	MGI:3804036

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Ikbkb^tm2.1Cgn mutation (0 available); any Ikbkb mutation (56 available)
Ikbkb^tm2Cgn mutation (1 available); any Ikbkb mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mature B cell number ( J:79132 )

• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow

• the IgM^lowIgD⁺ mature B cell population is strongly diminished in the spleen by 3- to 4- fold

• B cell numbers in the lymph nodes are also strongly reduced

decreased B-1 B cell number ( J:79132 )

• B-1 B cell numbers are strongly decreased in the peritoneum cavity

decreased follicular B cell number ( J:79132 )

• follicular B cells are the most diminished B cell population in the spleen

decreased marginal zone B cell number ( J:79132 )

• marginal zone B cell numbers are reduced about 4-fold

immune system

decreased mature B cell number ( J:79132 )

• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow

• the IgM^lowIgD⁺ mature B cell population is strongly diminished in the spleen by 3- to 4- fold

• B cell numbers in the lymph nodes are also strongly reduced

decreased B-1 B cell number ( J:79132 )

• B-1 B cell numbers are strongly decreased in the peritoneum cavity

decreased follicular B cell number ( J:79132 )

• follicular B cells are the most diminished B cell population in the spleen

decreased marginal zone B cell number ( J:79132 )

• marginal zone B cell numbers are reduced about 4-fold

Allelic Composition	Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^tm2.1Cgn mutation (0 available); any Ikbkb mutation (56 available)
Ikbkb^tm2Cgn mutation (1 available); any Ikbkb mutation (56 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:85810 )

• CD4+ T cells are reduced by about 20% in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:85810 )

• CD8+ T cells are reduced by about 50% in the periphery

abnormal humoral immune response ( J:85810 )

• the antibody response to the T-dependent antigen NP-CG is delayed

decreased IgE level ( J:85810 )

• slight reduction in serum concentration of IgE following immunization with the T-dependent antigen NP-CG

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:85810 )

• CD4+ T cells are reduced by about 20% in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:85810 )

• CD8+ T cells are reduced by about 50% in the periphery

decreased IgE level ( J:85810 )

• slight reduction in serum concentration of IgE following immunization with the T-dependent antigen NP-CG

Allelic Composition	Ikbkb^tm2Cgn/Ikbkb^tm2Cgn Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^tm2Cgn mutation (1 available); any Ikbkb mutation (56 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:85810 )

• most of the reduction of CD4 T cells is due to missing regulatory and memory T cell subsets

decreased memory T cell number ( J:85810 )

• numbers of CD4+CD44+ and to a lesser extent CD8+CD44+, memory-type T cells are reduced

decreased regulatory T cell number ( J:85810 )

• numbers of CD4+CD25+ T cells (suppressor/regulatory T cells) are reduced

immune system

decreased CD4-positive, alpha-beta T cell number ( J:85810 )

• most of the reduction of CD4 T cells is due to missing regulatory and memory T cell subsets

decreased memory T cell number ( J:85810 )

• numbers of CD4+CD44+ and to a lesser extent CD8+CD44+, memory-type T cells are reduced

decreased regulatory T cell number ( J:85810 )

• numbers of CD4+CD25+ T cells (suppressor/regulatory T cells) are reduced

Allelic Composition	Ikbkb^tm2Cgn/Ikbkb^tm2Cgn Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^tm2Cgn mutation (1 available); any Ikbkb mutation (56 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:118336 )

• NF kappa b activation is completely blocked

liver/biliary system

liver/biliary system phenotype ( J:118336 )

N	• mice do not develop liver tumors or show liver steatosis in contrast to Ikbkg conditional mutants

Allelic Composition	Chuk^tm1Mpa/Chuk^tm1Mpa Ikbkb^tm2Cgn/Ikbkb^tm2Cgn Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuk^tm1Mpa mutation (0 available); any Chuk mutation (51 available)
Ikbkb^tm2Cgn mutation (1 available); any Ikbkb mutation (56 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:137861 )

• most mice die by 7 months of age

premature death ( J:137861 )

• most mice die by 7 months of age

liver/biliary system

abnormal bile duct morphology ( J:137861 )

• the number of intact small portal bile ducts is reduced compared to in wild-type mice and exhibit signs of severe chronic cholestasis

• unobstructed bile ducts exhibit damaged, flattened epithelium surrounded by inflammatory foci with lymphocyte and ceroid macrophage infiltrate unlike in wild-type mice

• however, small bile duct development is normal at birth

• as the portal bile ducts are destroyed bile leaks between neighboring cells and the blood-bile barrier is disrupted

abnormal bile canaliculus morphology ( J:137861 )

• altered tubular arrangements of hepatocytes and severe dilations of the bile canaliculi are observed along with the disappearance of microvilli, formation of blebs and thickening of the pericanalicular ectoplasm

intrahepatic cholestasis ( J:137861 )

• severe chronic cholestasis in the liver

jaundice ( J:137861 )

homeostasis/metabolism

increased circulating bilirubin level ( J:137861 )

increased circulating alanine transaminase level ( J:137861 )

growth/size/body

cachexia ( J:137861 )

postnatal growth retardation ( J:137861 )

immune system

increased susceptibility to endotoxin shock ( J:137861 )

• following exposure to LPS, mice exhibit increased liver failure and hepatocyte apoptosis compared to similarly treated wild-type mice or single homozygous mice

endocrine/exocrine glands

abnormal bile duct morphology ( J:137861 )

• the number of intact small portal bile ducts is reduced compared to in wild-type mice and exhibit signs of severe chronic cholestasis

• unobstructed bile ducts exhibit damaged, flattened epithelium surrounded by inflammatory foci with lymphocyte and ceroid macrophage infiltrate unlike in wild-type mice

• however, small bile duct development is normal at birth

• as the portal bile ducts are destroyed bile leaks between neighboring cells and the blood-bile barrier is disrupted

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