Phenotypes associated with this allele

• Allele Symbol: Ikbkb^tm2.1Cgn
• Allele Name: targeted mutation 2.1, University of Cologne
• Allele ID: MGI:2652652
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikbkb^tm2.1Cgn/Ikbkb^tm2.1Cgn	involves: C57BL/6	MGI:3851692
cn2	Cd19^tm1(cre)Cgn/Cd19^+ Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:3851694
cn3	Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:2679030

Genotype
MGI:3851692

hm1

• Allelic Composition: Ikbkb^tm2.1Cgn/Ikbkb^tm2.1Cgn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-6 secretion ( J:79132 )

• TNF-mediated IL-6 production is abolished in embryonic cells

Genotype
MGI:3851694

cn2

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

decreased mature B cell number ( J:79132 )

• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow

• the IgM^lowIgD⁺ mature B cell population is strongly diminished in the spleen by 3- to 4- fold

• B cell numbers in the lymph nodes are also strongly reduced

decreased B-1 B cell number ( J:79132 )

• B-1 B cell numbers are strongly decreased in the peritoneum cavity

decreased follicular B cell number ( J:79132 )

• follicular B cells are the most diminished B cell population in the spleen

decreased marginal zone B cell number ( J:79132 )

• marginal zone B cell numbers are reduced about 4-fold

immune system

decreased mature B cell number ( J:79132 )

• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow

• the IgM^lowIgD⁺ mature B cell population is strongly diminished in the spleen by 3- to 4- fold

• B cell numbers in the lymph nodes are also strongly reduced

decreased B-1 B cell number ( J:79132 )

• B-1 B cell numbers are strongly decreased in the peritoneum cavity

decreased follicular B cell number ( J:79132 )

• follicular B cells are the most diminished B cell population in the spleen

decreased marginal zone B cell number ( J:79132 )

• marginal zone B cell numbers are reduced about 4-fold

Genotype
MGI:2679030

cn3

• Allelic Composition: Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

immune system

decreased CD4-positive, alpha-beta T cell number ( J:85810 )

• CD4+ T cells are reduced by about 20% in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:85810 )

• CD8+ T cells are reduced by about 50% in the periphery

abnormal humoral immune response ( J:85810 )

• the antibody response to the T-dependent antigen NP-CG is delayed

decreased IgE level ( J:85810 )

• slight reduction in serum concentration of IgE following immunization with the T-dependent antigen NP-CG

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:85810 )

• CD4+ T cells are reduced by about 20% in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:85810 )

• CD8+ T cells are reduced by about 50% in the periphery

decreased IgE level ( J:85810 )

• slight reduction in serum concentration of IgE following immunization with the T-dependent antigen NP-CG