Phenotypes associated with this allele

• Allele Symbol: Tg(KRT14-cre)1Cgn
• Allele Name: transgene insertion 1, University of Cologne
• Allele ID: MGI:2652655
• Summary: 30 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Vegfa^tm2Gne/Vegfa^tm2Gne Lyz2^tm1(cre)Ifo/Lyz2^+ Tg(KRT14-cre)1Cgn/0	involves: 129 * C57BL/6 * CBA * FVB/N	MGI:5444295
cn2	Cebpa^tm1Gonz/Cebpa^+ Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366854
cn3	Cebpa^tm1Gonz/Cebpa^tm2Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366855
cn4	Cebpa^tm1Gonz/Cebpa^tm9Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366856
cn5	Cebpa^tm1Gonz/Cebpa^tm1Gonz Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366857
cn6	Myd88^tm1Aki/Myd88^tm1Aki Otulin^tm1c(EUCOMM)Hmgu/Otulin^tm1c(EUCOMM)Hmgu Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2	MGI:7256624
cn7	Lmnb1^tm1.1Sgy/Lmnb1^tm1.1Sgy Lmnb2^tm1.1Sgy/Lmnb2^tm1.1Sgy Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5285675
cn8	Lmnb1^tm1.1Sgy/Lmnb1^tm1.1Sgy Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5285681
cn9	Lmnb2^tm1.1Sgy/Lmnb2^tm1.1Sgy Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5285682
cn10	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5582487
cn11	Chuk^tm1Yhu/Chuk^tm1Yhu Tg(KRT14-cre)1Cgn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3817620
cn12	Otulin^tm1c(EUCOMM)Hmgu/Otulin^tm1c(EUCOMM)Hmgu Tg(KRT14-cre)1Cgn/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2	MGI:7256612
cn13	Ifnar1^tm1Agt/Ifnar1^tm1Agt Otulin^tm1c(EUCOMM)Hmgu/Otulin^tm1c(EUCOMM)Hmgu Tg(KRT14-cre)1Cgn/0	involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2	MGI:7256625
cn14	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(KRT14-cre)1Cgn/0	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:5582492
cn15	Rest^tm1.1Yasu/Rest^+ Tg(KRT14-cre)1Cgn/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:6241529
cn16	Rest^tm1.1Yasu/Rest^tm1.1Yasu Tg(KRT14-cre)1Cgn/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:6241532
cn17	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tnfrsf1a^tm2Gkl/Tnfrsf1a^tm2Gkl Tg(KRT14-cre)1Cgn/0	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:5582488
cn18	Chuk^tm1Mpa/Chuk^tm1Mpa Tg(KRT14-cre)1Cgn/?	involves: C57BL/6	MGI:3714173
cn19	Otulin^em1Gvl/Otulin^tm1c(EUCOMM)Hmgu Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA/2	MGI:7256600
cn20	Snap29^tm1c(EUCOMM)Wtsi/Snap29^tm1c(EUCOMM)Wtsi Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * C57BL/6N * DBA/2	MGI:5812300
cn21	Fadd^tm1Mpa/Fadd^tm1Mpa Mlkl^tm1.1Wsa/Mlkl^tm1.1Wsa Otulin^tm1c(EUCOMM)Hmgu/Otulin^tm1c(EUCOMM)Hmgu Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * C57BL/6N * DBA/2	MGI:7256619
cn22	Mlkl^tm1.1Wsa/Mlkl^tm1.1Wsa Otulin^tm1c(EUCOMM)Hmgu/Otulin^tm1c(EUCOMM)Hmgu Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * C57BL/6N * DBA/2	MGI:7256622
cn23	Otulin^tm1c(EUCOMM)Hmgu/Otulin^tm1c(EUCOMM)Hmgu Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * C57BL/6N * DBA/2	MGI:7256626
cn24	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Il22ra1^tm1Rsab/Il22ra1^tm1Rsab Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * DBA/2	MGI:5582486
cn25	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Il20ra^tm1Rsab/Il20ra^tm1Rsab Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * DBA/2	MGI:5582485
cn26	Trim16^tm1Gmma/Trim16^+ Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * DBA/2	MGI:6479658
cn27	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * DBA/2	MGI:5582490
cn28	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Il22^tm1Jcrd/Il22^tm1Jcrd Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * DBA/2	MGI:5582491
cn29	Trim16^tm1Gmma/Trim16^tm1Gmma Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * DBA/2	MGI:6479659
cn30	Dbi^tm2.1Smdp/Dbi^tm2.2Smdp Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:5538741

Genotype
MGI:5444295

cn1

• Allelic Composition: Vegfa^tm2Gne/Vegfa^tm2Gne; Lyz2^tm1(cre)Ifo/Lyz2⁺; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal wound healing ( J:189044 )

• during the early and middle phases of wound healing, mice exhibit reduced formation and vascularization of granulation tissue compared with control mice

Genotype
MGI:4366854

cn2

• Allelic Composition: Cebpa^tm1Gonz/Cebpa⁺; Cebpb^tm1Nerl/Cebpb^tm1Nerl; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

integument

integument phenotype ( J:154022 )

N • mice have normal epidermis

Genotype
MGI:4366855

cn3

• Allelic Composition: Cebpa^tm1Gonz/Cebpa^tm2Nerl; Cebpb^tm1Nerl/Cebpb^tm1Nerl; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

integument

increased keratinocyte proliferation ( J:154022 )

abnormal epidermis stratum corneum morphology ( J:154022 )

• intermediate phenotype

abnormal epidermis stratum granulosum morphology ( J:154022 )

• intermediate phenotype

shiny skin ( J:154022 )

cellular

increased keratinocyte proliferation ( J:154022 )

Genotype
MGI:4366856

cn4

• Allelic Composition: Cebpa^tm1Gonz/Cebpa^tm9Nerl; Cebpb^tm1Nerl/Cebpb^tm1Nerl; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

integument

increased keratinocyte proliferation ( J:154022 )

absent epidermis stratum corneum ( J:154022 )

parakeratosis ( J:154022 )

absent epidermis stratum granulosum ( J:154022 )

shiny skin ( J:154022 )

cellular

increased keratinocyte proliferation ( J:154022 )

Genotype
MGI:4366857

cn5

• Allelic Composition: Cebpa^tm1Gonz/Cebpa^tm1Gonz; Cebpb^tm1Nerl/Cebpb^tm1Nerl; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

mortality/aging

neonatal lethality, complete penetrance ( J:154022 )

• mice die within 5 to 8 hours of birth

growth/size/body

weight loss ( J:154022 )

• at birth mice loss weight rapidly likely due to severe transepithelial water loss without lipophilic barrier dysfunction

vision/eye

eyelids open at birth ( J:154022 )

integument

increased keratinocyte proliferation ( J:154022 )

• at E18.5

abnormal epidermal layer morphology ( J:154022 )

• the interfollicular epidermis exhibits an immature phenotype with fewer and smaller keratohyalin granules in the stratum granulosum and immature non-scaling stratum corneum and parakeratosis compared with wild-type mice

parakeratosis ( J:154022 )

shiny skin ( J:154022 )

tight skin ( J:154022 )

cellular

increased keratinocyte proliferation ( J:154022 )

• at E18.5

Genotype
MGI:7256624

cn6

• Allelic Composition: Myd88^tm1Aki/Myd88^tm1Aki; Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu}; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2

integument

integument phenotype ( J:312394 )

N • no skin lesions and normal epidermal thickness

Genotype
MGI:5285675

cn7

• Allelic Composition: Lmnb1^tm1.1Sgy/Lmnb1^tm1.1Sgy; Lmnb2^tm1.1Sgy/Lmnb2^tm1.1Sgy; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

mortality/aging

mortality/aging ( J:174963 )

N • mice are born at Mendelian frequency and survive for over 2 years

integument

integument phenotype ( J:174963 )

N • keratinocytes exhibit normal proliferation

N • mice exhibit normal skin and hair

abnormal keratinocyte morphology ( J:174963 )

• keratinocytes exhibit an increase in misshapen cell nuclei and nuclear blebs in culture compared with wild-type cells

• however, no polyploidy is observed

Genotype
MGI:5285681

cn8

• Allelic Composition: Lmnb1^tm1.1Sgy/Lmnb1^tm1.1Sgy; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

mortality/aging

mortality/aging ( J:174963 )

N • mice are born at Mendelian frequency and survive for over 2 years

Genotype
MGI:5285682

cn9

• Allelic Composition: Lmnb2^tm1.1Sgy/Lmnb2^tm1.1Sgy; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

mortality/aging

mortality/aging ( J:174963 )

N • mice are born at Mendelian frequency and survive for over 2 years

Genotype
MGI:5582487

cn10

• Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn; Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

integument

integument phenotype ( J:208995 )

N • mice reach adulthood without showing inflammatory skin lesions

Genotype
MGI:3817620

cn11

• Allelic Composition: Chuk^tm1Yhu/Chuk^tm1Yhu; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

integument

abnormal skin morphology ( J:141162 )

• at birth, some mice resemble Chuk^tm1Mpa homozygotes

epidermal hyperplasia ( J:141162 )

• some mice exhibit epidermal hyperplasia after birth

Genotype
MGI:7256612

cn12

• Allelic Composition: Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu}; Tg(KRT14-cre)1Cgn/0; Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2

immune system

immune system phenotype ( J:312394 )

N • normal circulating inflammatory cytokine and chemokine levels

integument

integument phenotype ( J:312394 )

N • no dermatitis and normal epidermal thickness up to age older than 40 weeks

Genotype
MGI:7256625

cn13

• Allelic Composition: Ifnar1^tm1Agt/Ifnar1^tm1Agt; Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu}; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2

immune system

immune system phenotype ( J:312394 )

N • normal circulating inflammatory cytokine and chemokine levels in most mice

dermatitis ( J:312394 )

• delineated inflamed skin lesions from age 6 weeks in some mice

integument

integument phenotype ( J:312394 )

N • no skin lesions and normal epidermal thickness in most mice

dermatitis ( J:312394 )

• delineated inflamed skin lesions from age 6 weeks in some mice

Genotype
MGI:5582492

cn14

• Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn; Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

integument

integument phenotype ( J:208995 )

N • mice reach adulthood without showing inflammatory skin lesions

Genotype
MGI:6241529

cn15

• Allelic Composition: Rest^tm1.1Yasu/Rest⁺; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

pigmentation

pigmentation phenotype ( J:230341 )

N • mice never form white spots

Genotype
MGI:6241532

cn16

• Allelic Composition: Rest^tm1.1Yasu/Rest^tm1.1Yasu; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

pigmentation

pigmentation phenotype ( J:230341 )

N • mice never form white spots

Genotype
MGI:5582488

cn17

• Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn; Tnfrsf1a^tm2Gkl/Tnfrsf1a^tm2Gkl; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

integument

skin inflammation ( J:208995 )

• at P7

• skin lesions progressively develop to severe skin inflammation by 4 weeks

epidermal hyperplasia ( J:208995 )

• at P7

skin lesions ( J:208995 )

• milder at P7 than in Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(KRT14-cre)1Cgn

• skin lesions progressively develop to severe skin inflammation by 4 weeks

immune system

skin inflammation ( J:208995 )

• at P7

• skin lesions progressively develop to severe skin inflammation by 4 weeks

Genotype
MGI:3714173

cn18

• Allelic Composition: Chuk^tm1Mpa/Chuk^tm1Mpa; Tg(KRT14-cre)1Cgn/?
• Genetic Background: involves: C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:122320 )

• pups die within a few hours of birth

homeostasis/metabolism

decreased circulating free fatty acids level ( J:122320 )

• free fatty acids and ceramide content are decreased in the outer layer of the epidermis

impaired skin barrier function ( J:122320 )

• skin on the limbs, tail and parts of the head show increased permeability

• however, skin on the body does not show increased permeability

increased cholesterol level ( J:122320 )

• cholesterol levels are mildly increased in the outer layer of the epidermis

growth/size/body

weight loss ( J:122320 )

• mice loose as much as 5% of their weight within 3 hours of birth

skeleton

skeleton phenotype ( J:122320 )

N • in contrast to Chuk^tm1.1Mpa homozygotes, mice do not have any skeletal abnormalities

integument

impaired skin barrier function ( J:122320 )

• skin on the limbs, tail and parts of the head show increased permeability

• however, skin on the body does not show increased permeability

abnormal skin morphology ( J:122320 )

• epidermis had increased vascularisation

• blood vessel diameter is increased within the epidermis

abnormal keratinocyte differentiation ( J:122320 )

• primary keratinocytes do not differentiate in medium with increased calcium

• however, keratinocytes differentiate normally in vivo

abnormal epidermis stratum corneum morphology ( J:122320 )

• free fatty acids and ceramide content are decreased in the outer layer of the epidermis

• lipid composition within the stratum corneum is altered resulting in defective epidermal barrier and increased transepidermal water loss

shiny skin ( J:122320 )

abnormal skin condition ( J:122320 )

• at birth skin is shiny, sticky and taut

cellular

abnormal keratinocyte differentiation ( J:122320 )

• primary keratinocytes do not differentiate in medium with increased calcium

• however, keratinocytes differentiate normally in vivo

Genotype
MGI:7256600

cn19

• Allelic Composition: Otulin^em1Gvl/Otulin^{tm1c(EUCOMM)Hmgu}; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA/2

immune system

dermatitis ( J:312394 )

• delineated inflamed skin lesions on back

integument

dermatitis ( J:312394 )

• delineated inflamed skin lesions on back

spontaneous skin ulceration ( J:312394 )

• delineated inflamed skin lesions on back

neoplasm

increased squamous cell carcinoma incidence ( J:312394 )

• verrucous carcinomas on back skin

Genotype
MGI:5812300

cn20

• Allelic Composition: Snap29^{tm1c(EUCOMM)Wtsi}/Snap29^{tm1c(EUCOMM)Wtsi}; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
• Cell Lines: EPD0065_4_B10

mortality/aging

neonatal lethality, complete penetrance ( J:236759 )

• pups die within a few hours after birth

growth/size/body

decreased birth body size ( J:236759 )

• slightly reduced body size

behavior/neurological

absent gastric milk in neonates ( J:236759 )

• none of the pups contain milk in their stomachs

cellular

abnormal keratinocyte differentiation ( J:236759 )

• marker analysis indicates disturbed epidermal differentiation of the epidermis

increased keratinocyte proliferation ( J:236759 )

homeostasis/metabolism

impaired skin barrier function ( J:236759 )

• newborns show severe functional impairment of the epidermal barrier

integument

decreased hair follicle number ( J:236759 )

• reduction of hair follicles down to 81% that of wild-type mice

abnormal epidermal layer morphology ( J:236759 )

• skin shows decreased deposition of neutral lipids and glucosylceramide in the epidermis

abnormal keratinocyte differentiation ( J:236759 )

• marker analysis indicates disturbed epidermal differentiation of the epidermis

abnormal corneocyte morphology ( J:236759 )

• corneocytes appear inhomogeneously filled with remnants of nondegraded organelles and electron-lucent vesicle-like structures compared to homogenously filled wild-type corneocytes

hyperkeratosis ( J:236759 )

• stratum corneum is thickened and its structure is condensed

abnormal epidermis stratum granulosum morphology ( J:236759 )

• the basket-like structure of the stratum granulosum is condensed in the epidermis

abnormal epidermal lamellar body morphology ( J:236759 )

• reduction of lamellar body contents in the epidermis

• diminished formation, maturation, and secretion of lamellar bodies

decreased keratohyalin granule number ( J:236759 )

• the number of profilaggrin containing keratohyalin granules in the upper stratum granulosum is decreased in the epidermis

acanthosis ( J:236759 )

abnormal skin appearance ( J:236759 )

• mice exhibit a congenital ichtyotic phenotype

scaly skin ( J:236759 )

tight skin ( J:236759 )

• skin is taut

abnormal skin physiology ( J:236759 )

• marker analysis indicates disturbed epidermal differentiation of the epidermis

increased keratinocyte proliferation ( J:236759 )

impaired skin barrier function ( J:236759 )

• newborns show severe functional impairment of the epidermal barrier

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
CEDNIK syndrome		DOID:0060337	OMIM:609528	J:236759

Genotype
MGI:7256619

cn21

• Allelic Composition: Fadd^tm1Mpa/Fadd^tm1Mpa; Mlkl^tm1.1Wsa/Mlkl^tm1.1Wsa; Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu}; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

immune system

immune system phenotype ( J:312394 )

N • normal circulating inflammatory cytokine levels

integument

integument phenotype ( J:312394 )

N • no skin lesions and normal epidermal thickness

Genotype
MGI:7256622

cn22

• Allelic Composition: Mlkl^tm1.1Wsa/Mlkl^tm1.1Wsa; Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu}; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

immune system

dermatitis ( J:312394 )

• delineated inflamed skin lesions on back

• no skin lesions in tail

integument

integument phenotype ( J:312394 )

N • no skin lesions and normal epidermal thickness in tail

dermatitis ( J:312394 )

• delineated inflamed skin lesions on back

• no skin lesions in tail

Genotype
MGI:7256626

cn23

• Allelic Composition: Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu}; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

integument

abnormal epidermal stem cell apoptosis ( J:312394 )

• increased hair follicle stem cell (HFSC) and interfollicular epidermis (IFE) cell apoptosis

abnormal keratinocyte differentiation ( J:312394 )

• in both skin lesions and non-lesional skin at age 7 weeks

abnormal epidermal stem cell proliferation ( J:312394 )

• hyperproliferation

• accelerated wound closure at day 2 and 4 post-wounding

• decelerated wound closure at day 8 post-wounding

sebaceous gland hypertrophy ( J:312394 )

• hypersebacea at age 7 weeks

epidermal cyst ( J:312394 )

• at wound sites after completion of re-epithelialization

impaired skin barrier function ( J:312394 )

• of back and tail skin lesions at age 7 weeks

• normal in non-lesional skin

dermatitis ( J:312394 )

• delineated inflamed skin lesions on back and tail from age P6 onwards

• infiltration of immune cells into lesional skin

epidermal hyperplasia ( J:312394 )

• of back and tail skin lesions at age 7 weeks

• normal epidermal thickness of non-lesional skin

skin lesions ( J:312394 )

• tumor-like lesions at wound sites after completion of re-epithelialization

spontaneous skin ulceration ( J:312394 )

• delineated inflamed skin lesions on back and tail from age P6 onwards

increased skin squamous cell carcinoma incidence ( J:312394 )

• verrucous carcinoma developed from back and tail skin lesions

neoplasm

increased skin squamous cell carcinoma incidence ( J:312394 )

• verrucous carcinoma developed from back and tail skin lesions

immune system

dermatitis ( J:312394 )

• delineated inflamed skin lesions on back and tail from age P6 onwards

• infiltration of immune cells into lesional skin

cellular

abnormal epidermal stem cell apoptosis ( J:312394 )

• increased hair follicle stem cell (HFSC) and interfollicular epidermis (IFE) cell apoptosis

abnormal keratinocyte differentiation ( J:312394 )

• in both skin lesions and non-lesional skin at age 7 weeks

abnormal epidermal stem cell proliferation ( J:312394 )

• hyperproliferation

• accelerated wound closure at day 2 and 4 post-wounding

• decelerated wound closure at day 8 post-wounding

endocrine/exocrine glands

sebaceous gland hypertrophy ( J:312394 )

• hypersebacea at age 7 weeks

homeostasis/metabolism

impaired skin barrier function ( J:312394 )

• of back and tail skin lesions at age 7 weeks

• normal in non-lesional skin

growth/size/body

epidermal cyst ( J:312394 )

• at wound sites after completion of re-epithelialization

embryo

embryo phenotype ( J:312394 )

N • born at normal Mendelian ratios

Genotype
MGI:5582486

cn24

• Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn; Il22ra1^tm1Rsab/Il22ra1^tm1Rsab; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * DBA/2

mortality/aging

mortality/aging ( J:208995 )

N • mice survive to adulthood

integument

skin inflammation ( J:208995 )

• delayed onset and decelerated development compared with Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(KRT14-cre)1Cgn

• mild inflammation at 7 weeks

• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks

epidermal hyperplasia ( J:208995 )

• at P8, milder than in Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(KRT14-cre)1Cgn

skin lesions ( J:208995 )

• delayed onset and decelerated development compared with Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(KRT14-cre)1Cgn

immune system

skin inflammation ( J:208995 )

• delayed onset and decelerated development compared with Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(KRT14-cre)1Cgn

• mild inflammation at 7 weeks

• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks

Genotype
MGI:5582485

cn25

• Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn; Il20ra^tm1Rsab/Il20ra^tm1Rsab; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * DBA/2

mortality/aging

premature death ( J:208995 )

• severe inflammation requiring euthanasia by P25 in some mice

integument

skin inflammation ( J:208995 )

• delayed onset and decelerated development compared with Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(KRT14-cre)1Cgn

skin lesions ( J:208995 )

• delayed onset and decelerated development compared with Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(KRT14-cre)1Cgn

immune system

skin inflammation ( J:208995 )

• delayed onset and decelerated development compared with Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(KRT14-cre)1Cgn

Genotype
MGI:6479658

cn26

• Allelic Composition: Trim16^tm1Gmma/Trim16⁺; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * DBA/2

neoplasm

increased incidence of tumors by chemical induction ( J:290272 )

• mice show increased incidence of DMBA and TPA-induced papillomas compared to wild-type mice and homozygotes

• 3 of 30 DMBA and TPA treated mice develop squamous cell carcinomas which are not seen in treated controls

• DMBA and TPA treated mice show an increase in the number of melanomas at 15 weeks compared to wild-type, with mice developing both small and large melanoma lesions after 21 weeks of TPA treatment compared to only small lesions in wild-type mice

increased metastatic potential ( J:290272 )

• 6 of 33 DMBA/TPA-treated mice show pigmentation in a number of inguinal lymph nodes, suggesting metastatic melanoma

decreased tumor latency ( J:290272 )

• DMBA and TPA treated mice show an increase in the development of papillomas at 13 and 15 weeks, but not weeks 18 and 21, indicating a decrease in latency of papilloma development

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:290272 )

• mice show increased incidence of DMBA and TPA-induced papillomas compared to wild-type mice and homozygotes

• 3 of 30 DMBA and TPA treated mice develop squamous cell carcinomas which are not seen in treated controls

• DMBA and TPA treated mice show an increase in the number of melanomas at 15 weeks compared to wild-type, with mice developing both small and large melanoma lesions after 21 weeks of TPA treatment compared to only small lesions in wild-type mice

Genotype
MGI:5582490

cn27

• Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * DBA/2

integument

skin inflammation ( J:208995 )

• psoriasis-like skin inflammation

• inflammatory infiltrate consists mainly of macrophages and dendritic cells rather than CD3+ T lymphocytes

psoriasis ( J:208995 )

• psoriasis-like skin inflammation

immune system

skin inflammation ( J:208995 )

• psoriasis-like skin inflammation

• inflammatory infiltrate consists mainly of macrophages and dendritic cells rather than CD3+ T lymphocytes

Genotype
MGI:5582491

cn28

• Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn; Il22^tm1Jcrd/Il22^tm1Jcrd; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * DBA/2

mortality/aging

postnatal lethality, incomplete penetrance ( J:208995 )

• before P9

integument

skin inflammation ( J:208995 )

• severe

skin lesions ( J:208995 )

• severe

immune system

skin inflammation ( J:208995 )

• severe

Genotype
MGI:6479659

cn29

• Allelic Composition: Trim16^tm1Gmma/Trim16^tm1Gmma; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * DBA/2

neoplasm

neoplasm ( J:290272 )

N • mice show similar development of DMBA and TPA-induced papillomas as wild-type mice, with no development of squamous cell carcinoma

N • mice show a similar incidence of DMBA/TPA-induced cutaneous melanomas as wild-type mice

increased tumor growth/size ( J:290272 )

• DMBA and TPA treated mice develop larger melanoma lesions than wild-type mice after 21 weeks of TPA treatment

behavior/neurological

behavior/neurological phenotype ( J:290272 )

N • mice exhibit normal food consumption

Genotype
MGI:5538741

cn30

• Allelic Composition: Dbi^tm2.1Smdp/Dbi^tm2.2Smdp; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

integument

impaired skin barrier function ( J:204137 )

• compromised epidermal barrier function at postnatal day 21

greasy coat ( J:204137 )

• greasy and tousled appearance identical to that in homozygous germ line null mice

adipose tissue

abnormal white adipose tissue physiology ( J:204137 )

• elevated lypolysis in isolated inguinal WAT

homeostasis/metabolism

impaired skin barrier function ( J:204137 )

• compromised epidermal barrier function at postnatal day 21

increased liver cholesterol level ( J:204137 )

• greater accumulation of cholesteryl esters at P21

• accumulation is less than in homozygous germ line null mice

liver/biliary system

increased liver cholesterol level ( J:204137 )

• greater accumulation of cholesteryl esters at P21

• accumulation is less than in homozygous germ line null mice

abnormal liver physiology ( J:204137 )

• expression analysis in fostered pups indicates a defect in liver adaptation to weaning