All Phenotypes Ogg1<tm1Yun> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6J	MGI:2653016
hm2	Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476991
cx3	Mutyh^tm1Yun/Mutyh^tm1Yun Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	B6JJcl.129-Mutyh^tm1Yun Nudt1^tm1Tts Ogg1^tm1Yun	MGI:5476986
cx4	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6J	MGI:2653017
cx5	Mutyh^tm1Yun/Mutyh^tm1Yun Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476987
cx6	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476988

Allelic Composition	Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lung adenoma incidence ( J:82287 )

• spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth

increased lung carcinoma incidence ( J:82287 )

• spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth

respiratory system

increased lung adenoma incidence ( J:82287 )

• spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth

increased lung carcinoma incidence ( J:82287 )

• spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth

Allelic Composition	Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:193978 )

microgliosis ( J:193978 )

neurodegeneration ( J:193978 )

behavior/neurological

decreased vertical activity ( J:193978 )

decreased locomotor activity ( J:193978 )

cellular

increased susceptibility to neuronal excitotoxicity ( J:193978 )

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:193978 )

immune system

microgliosis ( J:193978 )

hematopoietic system

microgliosis ( J:193978 )

Allelic Composition	Mutyh^tm1Yun/Mutyh^tm1Yun Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	B6JJcl.129-Mutyh^tm1Yun Nudt1^tm1Tts Ogg1^tm1Yun

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyh^tm1Yun mutation (2 available); any Mutyh mutation (36 available)
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (31 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:193978 )

• mice are highly susceptible to spontaneous tumorigenesis within 100 days of birth

Allelic Composition	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (31 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:82287 )

N	• no tumors in the lungs of double knockout mice, unlike Ogg^tm1Skmi single knockout mice

Allelic Composition	Mutyh^tm1Yun/Mutyh^tm1Yun Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyh^tm1Yun mutation (2 available); any Mutyh mutation (36 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1^tm1Skmi homozygotes

cellular

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1^tm1Skmi homozygotes

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1^tm1Skmi homozygotes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

neurodegeneration ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:193978 )

• 3-NP treated mice exhibit increased motor impairment (neurological score based on: general slowness of displacement resulting from mild hindlimb impairment;, incoordination and marked gait abnormality; hindlimb paralysis; incapacity to move resulting from forelimb and hindlimb impairment) compared with wild-type mice

decreased vertical activity ( J:193978 )

• in 3-NP-treated mice

decreased locomotor activity ( J:193978 )

• 3-NP-treated mice travel less distance in an open-field test compared with wild-type mice that is more severe than in Ogg1^tm1Skmi homozygotes

• 3-NP-treated mice are hypoactive in home cages compared with wild-type mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

cellular

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

abnormal single-strand DNA break repair ( J:193978 )

• 3-NP treated mice exhibit an accumulation of 8-oxoG that results in the accumulation of single strand breaks in mitochondrial DNA of striatal medium spiny neurons and nuclear DNA of striatal microglia compared with wild-type mice

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

abnormal single-strand DNA break repair ( J:193978 )

immune system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

hematopoietic system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

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