Analysis Tools
normal phenotype
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• mice are viable and fertile and develop normally, with no anomalies detected in pancreatic islet morphology, beta-cell mass or pancreatic secretory function
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Allele Symbol Allele Name Allele ID |
Insrrtm1Dac targeted mutation 1, Domenico Accili MGI:2653019 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable and fertile and develop normally, with no anomalies detected in pancreatic islet morphology, beta-cell mass or pancreatic secretory function
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• XY mice at E17.5 showed gonad location and histology consistent with ovary development
• cause inferred as decrease in proliferation of Sry -expressing cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• XY mice may develop testes, ovotestes, and/or ovaries
• gonad type is suggested by degree of gonadal descent and histological analyses
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die within 5 days of birth
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• similar to Insr mutant mice; plasma glucose levels rose sharply after birth
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• similar to Insr mutant mice; plasma insulin levels rose sharply after birth
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• compound homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine
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• compound homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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