Phenotypes associated with this allele

• Allele Symbol: Insrr^tm1Dac
• Allele Name: targeted mutation 1, Domenico Accili
• Allele ID: MGI:2653019
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S1/Sv * C57BL/6J	MGI:3035939
cx2	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:3575085
cx3	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^+ Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:3575092
cx4	Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:2653026

Genotype
MGI:3035939

hm1

• Allelic Composition: Insrr^tm1Dac/Insrr^tm1Dac
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:70602 )

• mice are viable and fertile and develop normally, with no anomalies detected in pancreatic islet morphology, beta-cell mass or pancreatic secretory function

Genotype
MGI:3575085

cx2

• Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge; Insr^tm1Dac/Insr^tm1Dac; Insrr^tm1Dac/Insrr^tm1Dac
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

reproductive system

abnormal primary sex determination ( J:86618 )

primary sex reversal ( J:86618 )

• XY mice at E17.5 showed gonad location and histology consistent with ovary development

• cause inferred as decrease in proliferation of Sry -expressing cells

Genotype
MGI:3575092

cx3

• Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge; Insr^tm1Dac/Insr⁺; Insrr^tm1Dac/Insrr^tm1Dac
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

reproductive system

abnormal primary sex determination ( J:86618 )

primary sex reversal ( J:86618 )

• XY mice may develop testes, ovotestes, and/or ovaries

• gonad type is suggested by degree of gonadal descent and histological analyses

Genotype
MGI:2653026

cx4

• Allelic Composition: Insr^tm1Dac/Insr^tm1Dac; Insrr^tm1Dac/Insrr^tm1Dac
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

mortality/aging

postnatal lethality, complete penetrance ( J:70602 )

• mice die within 5 days of birth

homeostasis/metabolism

hyperglycemia ( J:70602 )

• similar to Insr mutant mice; plasma glucose levels rose sharply after birth

increased circulating insulin level ( J:70602 )

• similar to Insr mutant mice; plasma insulin levels rose sharply after birth

impaired glucose tolerance ( J:70602 )

ketoaciduria ( J:70602 )

• compound homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine

renal/urinary system

ketoaciduria ( J:70602 )

• compound homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine