All Phenotypes Htr1b<tm1Rhn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Htr1b^tm1Rhn
targeted mutation 1, Rene Hen
MGI:2653030

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htr1b^tm1Rhn/Htr1b^tm1Rhn	involves: 129S2/SvPas	MGI:2653033
hm2	Htr1b^tm1Rhn/Htr1b^tm1Rhn	involves: 129S2/SvPas * 129S6/SvEvTac	MGI:3604732
ht3	Htr1b^tm1Rhn/Htr1b⁺	involves: 129S2/SvPas	MGI:3837411
cn4	Creb1^tm3Gsc/Creb1⁺ Htr1b^tm1Rhn/Htr1b^tm1Rhn Tg(Col1a1-cre)1Kry/0	involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N	MGI:3837414
cn5	Htr1b^tm1Rhn/Htr1b⁺ Tph1^tm1Kry/Tph1⁺ Tg(Vil1-cre)20Syr/0	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:3837413
cx6	Htr1b^tm1Rhn/Htr1b⁺ Lrp5^tm1Kry/Lrp5^tm1Kry	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3837416
cx7	Htr1b^tm1Rhn/Htr1b^tm1Rhn Slc6a4^tm1Kpl/Slc6a4^tm1Kpl	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3710370

Allelic Composition	Htr1b^tm1Rhn/Htr1b^tm1Rhn
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial learning ( J:96221 )

• long-term spatial learning is improved in aged mice

• attenuation of age related decline in learning

• less effect on short-term spatial learning

increased fluid intake ( J:96318 )

• drink more than sex matched controls

increased aggression towards male mice ( J:20209 )

• both frequency and intensity of aggression increased

• latency to aggressive attacks reduced

• only results with males reported

decreased anxiety-related response ( J:96656 )

• observed as reduced burying behavior

decreased startle reflex ( J:96460 )

• reduced reactivity and less readily sensitized

abnormal locomotor activation ( J:96221 )

• higher swimming speed

cellular

increased osteoblast proliferation ( J:146078 )

• increased osteoblast proliferation

growth/size/body

increased body weight ( J:96318 , J:96460 )

• higher body weights throughout life (J:96318)

reproductive system

small testis ( J:96318 )

skeleton

increased osteoblast proliferation ( J:146078 )

• increased osteoblast proliferation

increased osteoblast cell number ( J:146078 )

• at 1 and 3 months of age

increased bone mass ( J:146078 )

• at 1 and 3 months of age

increased bone ossification ( J:146078 )

• increased bone formation at 1 and 3 months of age

endocrine/exocrine glands

small testis ( J:96318 )

Allelic Composition	Htr1b^tm1Rhn/Htr1b^tm1Rhn
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal operant conditioning behavior ( J:96223 )

• "acquired autoshaping" occurs more rapidly

Allelic Composition	Htr1b^tm1Rhn/Htr1b⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased osteoblast cell number ( J:146078 )

• at 1 and 3 months of age

increased bone mass ( J:146078 )

• at 1 and 3 months of age

increased bone ossification ( J:146078 )

• increased bone formation at 1 and 3 months of age

Allelic Composition	Creb1^tm3Gsc/Creb1⁺ Htr1b^tm1Rhn/Htr1b^tm1Rhn Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1^tm3Gsc mutation (2 available); any Creb1 mutation (61 available)
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (26 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:146078 )

N	• loss of expression of 1 copy of Creb1 in osteoblasts rescues the bone phenotype seen in Htrb1 null mice

Allelic Composition	Htr1b^tm1Rhn/Htr1b⁺ Tph1^tm1Kry/Tph1⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (26 available)
Tg(Vil1-cre)20Syr mutation (4 available)
Tph1^tm1Kry mutation (0 available); any Tph1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mass ( J:146078 )

• phenotype is the same as in mice homozygous null for Htr1b and mice conditional null for Tph1 in the gut

Allelic Composition	Htr1b^tm1Rhn/Htr1b⁺ Lrp5^tm1Kry/Lrp5^tm1Kry
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (26 available)
Lrp5^tm1Kry mutation (0 available); any Lrp5 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:146078 )

N	• loss of expression of 1 copy of Htrb1 rescues the bone phenotype seen in Lrp5 null mice

Allelic Composition	Htr1b^tm1Rhn/Htr1b^tm1Rhn Slc6a4^tm1Kpl/Slc6a4^tm1Kpl
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (26 available)
Slc6a4^tm1Kpl mutation (3 available); any Slc6a4 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart valve morphology ( J:121505 )

• valvular fibrosis

heart valve hyperplasia ( J:121505 )

• leaflet thickening in valvular regions

cardiac fibrosis ( J:121505 )

• fibrosis in myocardial and valvular regions

dilated cardiomyopathy ( J:121505 )

• increased left ventricular lumen diameter and myocardial hypokinesis (decreased fractional shortening)

decreased cardiac muscle contractility ( J:121505 )

• decreased fractional shortening

muscle

dilated cardiomyopathy ( J:121505 )

• increased left ventricular lumen diameter and myocardial hypokinesis (decreased fractional shortening)

decreased cardiac muscle contractility ( J:121505 )

• decreased fractional shortening

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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