Phenotypes associated with this allele

• Allele Symbol: Bfsp2^tm1Raq
• Allele Name: targeted mutation 1, Roy A Quinlan
• Allele ID: MGI:2653265
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bfsp2^tm1Raq/Bfsp2^tm1Raq	involves: 129P2/OlaHsd	MGI:3815513

Genotype
MGI:3815513

hm1

• Allelic Composition: Bfsp2^tm1Raq/Bfsp2^tm1Raq
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens fiber morphology ( J:82327 )

• the cytoskeleton of lens fiber cells is abnormal, with both smooth and beaded filaments being replaced by poorly defined electron-dense material

• cortical fiber cell membranes lack lateral interdigitations that typically arise at the angles formed by the six fiber faces and are usually arrayed along the cell length

• the width and thickness of knockout lens fiber cells are quite variable along their length giving these fibers the appearance of liquid drops on a string

abnormal vision ( J:82327 )

• average back focal length of mice is 1.77 mm compared to 1.066 mm in wild-type mice

• the variability of the back focal lengths from mouse to mouse is larger than in wild-type mice

increased corneal light-scattering ( J:82327 )

• all lenses have a perinuclear haze that is greater than what is observed in wild-type mice

cellular

abnormal cell cytoskeleton morphology ( J:82327 )

• the cytoskeleton of lens fiber cells is abnormal, with both smooth and beaded filaments being replaced by poorly defined electron-dense material