About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpm5tm1Csz
targeted mutation 1, Charles S Zuker
MGI:2653340
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpm5tm1Csz/Trpm5tm1Csz involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2653341
cx2
 		Trpm4tm1.1Knt/Trpm4tm1.1Knt
Trpm5tm1Csz/Trpm5tm1Csz 		involves: 129S1/Sv * 129X1/SvJ MGI:3817414


Genotype
MGI:2653341
hm1
Allelic
Composition		 Trpm5tm1Csz/Trpm5tm1Csz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm5tm1Csz mutation (1 available); any Trpm5 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal gustatory system physiology ( J:82314 )
• normal nerve responses to salty or sour stimuli
• nerve responses to sweet, amino acid, and bitter stimuli were abolished
abnormal taste sensitivity ( J:82314 )
• preference for sweet, amino acid or bitter vs. water abolished
• preference for salty or sour vs. water similar to controls




Genotype
MGI:3817414
cx2
Allelic
Composition		 Trpm4tm1.1Knt/Trpm4tm1.1Knt
Trpm5tm1Csz/Trpm5tm1Csz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm4tm1.1Knt mutation (0 available); any Trpm4 mutation (59 available)
Trpm5tm1Csz mutation (1 available); any Trpm5 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased dendritic cell number ( J:140991 )
• in the spleen compared to Trpm5tm1Csz homozygotes

immune system
decreased dendritic cell number ( J:140991 )
• in the spleen compared to Trpm5tm1Csz homozygotes
abnormal dendritic cell physiology ( J:140991 )
• activated dendritic cells exhibit increased calcium ion concentrations compared to in Trpm5tm1Csz homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory