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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpm5tm1Csz
targeted mutation 1, Charles S Zuker
MGI:2653340
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpm5tm1Csz/Trpm5tm1Csz involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2653341
cx2
 		Trpm4tm1.1Knt/Trpm4tm1.1Knt
Trpm5tm1Csz/Trpm5tm1Csz 		involves: 129S1/Sv * 129X1/SvJ MGI:3817414


Genotype
MGI:2653341
hm1
Allelic
Composition		 Trpm5tm1Csz/Trpm5tm1Csz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm5tm1Csz mutation (1 available); any Trpm5 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal gustatory system physiology ( J:82314 )
• nerve responses to sweet, amino acid, and bitter stimuli were abolished
• normal nerve responses to salty or sour stimuli
abnormal taste sensitivity ( J:82314 )
• preference for sweet, amino acid or bitter vs. water abolished
• preference for salty or sour vs. water similar to controls




Genotype
MGI:3817414
cx2
Allelic
Composition		 Trpm4tm1.1Knt/Trpm4tm1.1Knt
Trpm5tm1Csz/Trpm5tm1Csz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm4tm1.1Knt mutation (0 available); any Trpm4 mutation (59 available)
Trpm5tm1Csz mutation (1 available); any Trpm5 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased dendritic cell number ( J:140991 )
• in the spleen compared to Trpm5tm1Csz homozygotes

immune system
decreased dendritic cell number ( J:140991 )
• in the spleen compared to Trpm5tm1Csz homozygotes
abnormal dendritic cell physiology ( J:140991 )
• activated dendritic cells exhibit increased calcium ion concentrations compared to in Trpm5tm1Csz homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory