• aging double homozygotes display lipid accumulation around the blood-CSF barrier, the blood-brain barrier, and specific brain regions including the lateral ventricle, third ventricle, cerebral aqueduct, fourth ventricle, median eminence subfornical organ, and organum vasculosum of the lamina terminalis, as well as the pars reticularis of substantia nigra, globus pallidus, and subthalamic nucleus
• in these regions, lipid-laden cells are observed primarily around the blood vessels
• a marked accumulation of ApoE protein is noted in substantia nigra and cells surrounding the lateral ventricle; ApoE-positive cells are also found around blood vessels in the cerebral cortex