Phenotypes associated with this allele

• Allele Symbol: Lipg^tm1Chan
• Allele Name: targeted mutation 1, Lawrence Chan
• Allele ID: MGI:2653887
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lipg^tm1Chan/Lipg^tm1Chan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2653898
ht2	Lipg^tm1Chan/Lipg^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2653899

Genotype
MGI:2653898

hm1

• Allelic Composition: Lipg^tm1Chan/Lipg^tm1Chan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating phospholipid level ( J:82390 )

• 52.8% increase in total plasma phospholipid level compared to wild-type mice when fed a regular chow diet

• 47.6% increase in total plasma phospholipid level compared to wild-type mice when fed a high cholesterol diet

abnormal cholesterol homeostasis ( J:82390 )

• delay in HDL cholesterol clearance

increased circulating cholesterol level ( J:82390 )

• mutants fed a regular chow diet exhibit a 42.6% increase in plasma cholesterol compared to wild-type mice

• mutants fed a high cholesterol diet exhibit a 53.2% increase in plasma cholesterol compared to wild-type mice

increased circulating HDL cholesterol level ( J:82390 )

• 55.7% increase in HDL-c levels compared to wild-type mice when fed a regular chow diet

• 51.4% increase in HDL-c levels compared to wild-type mice when fed a high cholesterol diet

• mutants have increased numbers of large-sized HDL particles

Genotype
MGI:2653899

ht2

• Allelic Composition: Lipg^tm1Chan/Lipg⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:82390 )

• delay in HDL cholesterol clearance

increased circulating cholesterol level ( J:82390 )

• 28.2% increase in plasma cholesterol levels when fed a regular chow diet compared to wild-type mice

increased circulating HDL cholesterol level ( J:82390 )

• 22.8% increase in HDL-c levels compared to wild-type mice