All Phenotypes Brca2<tm2Hst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brca2^tm2Hst
targeted mutation 2, Paul Hasty
MGI:2653914

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca2^tm2Hst/Brca2^tm2Hst	involves: 129S7/SvEvBrd * C57BL/6	MGI:2653930
ht2	Brca2^tm1Hst/Brca2^tm2Hst	involves: 129S7/SvEvBrd * C57BL/6	MGI:2653931

Allelic Composition	Brca2^tm2Hst/Brca2^tm2Hst
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm2Hst mutation (0 available); any Brca2 mutation (132 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:82434 )

Allelic Composition	Brca2^tm1Hst/Brca2^tm2Hst
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Hst mutation (0 available); any Brca2 mutation (132 available)
Brca2^tm2Hst mutation (0 available); any Brca2 mutation (132 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

early cellular replicative senescence ( J:82434 )

• primary MEFs senesce prematurely in culture

chromosomal instability ( J:82434 )

• primary MEFs have higher numbers of chromosomal aberrations even at passage 2 and accumulate further aberrations more rapidly than wild-type MEFs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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