Phenotypes associated with this allele

• Allele Symbol: Ppp1r3a^tm1Adpr
• Allele Name: targeted mutation 1, Anna A DePaoli-Roach
• Allele ID: MGI:2653989
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r3a^tm1Adpr/Ppp1r3a^tm1Adpr	either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J)	MGI:2654005

Genotype
MGI:2654005

hm1

• Allelic Composition: Ppp1r3a^tm1Adpr/Ppp1r3a^tm1Adpr
• Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased skeletal muscle glycogen level ( J:68370 )

• accumulation of glycogen is decreased by about 90% in skeletal muscle, however mice remain normoglycemic and are insulin responsive

abnormal enzyme/coenzyme activity ( J:68370 )

• the glycogen synthase activity ratio in the absence and presence of glucose-6-phosphate is reduced in skeletal muscle

• the phosphorylase activity ratio in the absence and presence of AMP is increased in skeletal muscle

muscle

decreased skeletal muscle glycogen level ( J:68370 )

• accumulation of glycogen is decreased by about 90% in skeletal muscle, however mice remain normoglycemic and are insulin responsive