Analysis Tools
behavior/neurological
hematopoietic system
homeostasis/metabolism
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• more than 10 times the nomral levels of creatinine
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• elevation in urea
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albuminuria
(
J:82440
)
renal/urinary system
albuminuria
(
J:82440
)
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• renal lesions are first detected at 2.5 weeks of age with swelling of the endothelial cells and hyaline deposits
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• no patent capillary loops can be seen at 9 weeks of age
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• at 2.5 weeks of age, mice display swelling of the endothelial cells (endotheliosis)
• endothelial cells become necrotic by 9 weeks of age
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• endothelial fenestrations are no longer identifiable by 9 weeks of age
• however, well-formed endothelial fenestrations are present at 2.5 weeks of age
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• podocytes containing large empty cytoplasmic vacuoles are seen by 9 weeks of age
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• no podocyte foot processes are identifiable by 9 weeks of age
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• at 6.5 weeks of age, the glomerular basement membrane is expanded
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• expansion of the mesangial matrix is seen by 9 weeks of age
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• hyaline deposits are first detected at 2.5 weeks of age
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• pale, shrunken kidneys at 9 weeks of age
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• glomerular tufts are retracted by 9 weeks of age
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• dilated tubules can be seen at 9 weeks of age
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renal cast
(
J:82440
)
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• dilated tubules are packed with proteinaceous material in most places
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pale kidney
(
J:82440
)
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• at 9 weeks of age
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• develop end-stage kidney failure by 9-12 weeks of age
• no gross signs of renal failure prior to 7-8 weeks of age
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integument
cardiovascular system
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• no patent capillary loops can be seen at 9 weeks of age
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• at 2.5 weeks of age, mice display swelling of the endothelial cells (endotheliosis)
• endothelial cells become necrotic by 9 weeks of age
|
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• endothelial fenestrations are no longer identifiable by 9 weeks of age
• however, well-formed endothelial fenestrations are present at 2.5 weeks of age
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