Analysis Tools
mortality/aging
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• death within 5 days of age
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growth/size/body
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• mice become growth retarded within 2 days after birth
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homeostasis/metabolism
albuminuria
(
J:82440
)
|
• seen by 5 days of age
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renal/urinary system
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• kidneys are hyperemic and exhibit cortical hemorrhages
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• podocytes detach from the basement membrane
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albuminuria
(
J:82440
)
|
• seen by 5 days of age
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• Bowman's space is enlarged
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• podocytes are abnormal and detach from the basement membrane
• by 9 weeks of age, most glomeruli show a complete absence of markers of podocyte differentiation
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|
• global collapse of the capillary tuft toward the vascular pole of the glomerulus is seen at 5 days of age
|
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• total collapse of the capillary network is seen at 5 days of age
• only a few patent capillary loops of an increased diameter are detected at 5 days of age, unlike in wild-type glomeruli
• multiple endothelial cell nuclei are found within the few remaining patent capillary loops, not seen in wild-type glomeruli
|
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• no endothelial cells can be identified by 5 days of age
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• only a few patent capillary loops of an increased diameter are detected at 5 days of age, unlike in wild-type glomeruli
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• mesangial cells are present but appear to surround the collapsed glomerulus in a crescent shape
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• collapsed capillary loops, cortical hemorrhage, dilation of proximal tubules
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• dilated proximal tubules are packed with protein
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renal cast
(
J:82440
)
|
• dilated proximal tubules are packed with protein
|
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• end-stage renal failure due to a collapsing glomerulopathy
|
cardiovascular system
|
• total collapse of the capillary network is seen at 5 days of age
• only a few patent capillary loops of an increased diameter are detected at 5 days of age, unlike in wild-type glomeruli
• multiple endothelial cell nuclei are found within the few remaining patent capillary loops, not seen in wild-type glomeruli
|
|
• no endothelial cells can be identified by 5 days of age
|
|
• only a few patent capillary loops of an increased diameter are detected at 5 days of age, unlike in wild-type glomeruli
|
|
• kidneys are hyperemic and exhibit cortical hemorrhages
|
cellular
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• mesangial cells are present but appear to surround the collapsed glomerulus in a crescent shape
|
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• podocytes detach from the basement membrane
|
