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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ddit3tm1Dron
targeted mutation 1, David Ron
MGI:2654034
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ddit3tm1Dron/Ddit3tm1Dron B6.129-Ddit3tm1Dron MGI:4398676
hm2
Ddit3tm1Dron/Ddit3tm1Dron either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) MGI:3700139
hm3
Ddit3tm1Dron/Ddit3tm1Dron involves: 129S1/Sv * 129X1/SvJ MGI:3777114
hm4
Ddit3tm1Dron/Ddit3tm1Dron involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3700148
cx5
Ddit3tm1Dron/Ddit3tm1Dron
Mpztm3.1Wra/Mpztm3.1Wra
involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N MGI:6191700
cx6
Ddit3tm1Dron/Ddit3tm1Dron
Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 MGI:5788485


Genotype
MGI:4398676
hm1
Allelic
Composition
Ddit3tm1Dron/Ddit3tm1Dron
Genetic
Background
B6.129-Ddit3tm1Dron
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation (1 available); any Ddit3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages
• macrophages treated with excess lipoprotein-cholesterol or tunicamycin fail to exhibit an increase in IP3-induced calcium release unlike similarly wild-type

cellular
• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages

hematopoietic system
• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages
• macrophages treated with excess lipoprotein-cholesterol or tunicamycin fail to exhibit an increase in IP3-induced calcium release unlike similarly wild-type




Genotype
MGI:3700139
hm2
Allelic
Composition
Ddit3tm1Dron/Ddit3tm1Dron
Genetic
Background
either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation (1 available); any Ddit3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• homozygotes treated with tunicamycin to induce ER stress and renal insufficiency exhibit decreased programmed cell death in the renal proximal tubular epithelium
• MEFs prepared from E13.5 embryos exhibit less programmed cell death when challenged with agents that perturb ER function

homeostasis/metabolism
• homozygotes treated with tunicamycin to induce ER stress and renal insufficiency exhibit decreased programmed cell death in the renal proximal tubular epithelium compared to controls despite impaired renal function




Genotype
MGI:3777114
hm3
Allelic
Composition
Ddit3tm1Dron/Ddit3tm1Dron
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation (1 available); any Ddit3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• homozygotes have a normal pancreas




Genotype
MGI:3700148
hm4
Allelic
Composition
Ddit3tm1Dron/Ddit3tm1Dron
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation (1 available); any Ddit3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• homozygotes infected with a neurovirulent virus, Moloney MLV-ts1, exhibit a small, but significant, delay of about 4.5 days in the incubation period of the disease that correlates with a decrease in early virus replication




Genotype
MGI:6191700
cx5
Allelic
Composition
Ddit3tm1Dron/Ddit3tm1Dron
Mpztm3.1Wra/Mpztm3.1Wra
Genetic
Background
involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation (1 available); any Ddit3 mutation (20 available)
Mpztm3.1Wra mutation (0 available); any Mpz mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show no improvement in rotarod function, with nice unable to retain balance on the rotarod

nervous system
• mice show no morphological changes in myelin, showing very thin, if any, myelin in sciatic nerves
• mice show no improvement in myelination
• mice show no changes in nerve conduction velocities, showing severely slowed nerve conduction velocities at 6-8 weeks of age




Genotype
MGI:5788485
cx6
Allelic
Composition
Ddit3tm1Dron/Ddit3tm1Dron
Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0
Genetic
Background
involves: 129X1/SvJ * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation (1 available); any Ddit3 mutation (20 available)
Tg(Col2a1-rtTA,tetO-COMP*)2Jath mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• doxycycline treated mice show decreased levels of inflammatory markers in the growth plate compared to Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0 mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory