All Phenotypes Ddit3<tm1Dron> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ddit3^tm1Dron
targeted mutation 1, David Ron
MGI:2654034

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddit3^tm1Dron/Ddit3^tm1Dron	B6.129-Ddit3^tm1Dron	MGI:4398676
hm2	Ddit3^tm1Dron/Ddit3^tm1Dron	either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:3700139
hm3	Ddit3^tm1Dron/Ddit3^tm1Dron	involves: 129S1/Sv * 129X1/SvJ	MGI:3777114
hm4	Ddit3^tm1Dron/Ddit3^tm1Dron	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3700148
cx5	Ddit3^tm1Dron/Ddit3^tm1Dron Mpz^tm3.1Wra/Mpz^tm3.1Wra	involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N	MGI:6191700
cx6	Ddit3^tm1Dron/Ddit3^tm1Dron Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0	involves: 129X1/SvJ * 129S1/Sv * C57BL/6	MGI:5788485

Allelic Composition	Ddit3^tm1Dron/Ddit3^tm1Dron
Genetic Background	B6.129-Ddit3^tm1Dron

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3^tm1Dron mutation (1 available); any Ddit3 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased macrophage apoptosis ( J:153833 )

• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages

abnormal macrophage activation involved in immune response ( J:153833 )

• macrophages treated with excess lipoprotein-cholesterol or tunicamycin fail to exhibit an increase in IP3-induced calcium release unlike similarly wild-type

cellular

decreased macrophage apoptosis ( J:153833 )

• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages

hematopoietic system

decreased macrophage apoptosis ( J:153833 )

• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages

abnormal macrophage activation involved in immune response ( J:153833 )

• macrophages treated with excess lipoprotein-cholesterol or tunicamycin fail to exhibit an increase in IP3-induced calcium release unlike similarly wild-type

Allelic Composition	Ddit3^tm1Dron/Ddit3^tm1Dron
Genetic Background	either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3^tm1Dron mutation (1 available); any Ddit3 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased apoptosis ( J:52729 )

• homozygotes treated with tunicamycin to induce ER stress and renal insufficiency exhibit decreased programmed cell death in the renal proximal tubular epithelium

decreased fibroblast apoptosis ( J:52729 )

• MEFs prepared from E13.5 embryos exhibit less programmed cell death when challenged with agents that perturb ER function

homeostasis/metabolism

abnormal response to injury ( J:52729 )

• homozygotes treated with tunicamycin to induce ER stress and renal insufficiency exhibit decreased programmed cell death in the renal proximal tubular epithelium compared to controls despite impaired renal function

Allelic Composition	Ddit3^tm1Dron/Ddit3^tm1Dron
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3^tm1Dron mutation (1 available); any Ddit3 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:129974 )

N	• homozygotes have a normal pancreas

Allelic Composition	Ddit3^tm1Dron/Ddit3^tm1Dron
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3^tm1Dron mutation (1 available); any Ddit3 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to Retroviridae infection ( J:112354 )

• homozygotes infected with a neurovirulent virus, Moloney MLV-ts1, exhibit a small, but significant, delay of about 4.5 days in the incubation period of the disease that correlates with a decrease in early virus replication

Allelic Composition	Ddit3^tm1Dron/Ddit3^tm1Dron Mpz^tm3.1Wra/Mpz^tm3.1Wra
Genetic Background	involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3^tm1Dron mutation (1 available); any Ddit3 mutation (20 available)
Mpz^tm3.1Wra mutation (0 available); any Mpz mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:241742 )

• mice show no improvement in rotarod function, with nice unable to retain balance on the rotarod

nervous system

decreased myelin sheath thickness ( J:241742 )

• mice show no morphological changes in myelin, showing very thin, if any, myelin in sciatic nerves

dysmyelination ( J:241742 )

• mice show no improvement in myelination

decreased nerve conduction velocity ( J:241742 )

• mice show no changes in nerve conduction velocities, showing severely slowed nerve conduction velocities at 6-8 weeks of age

Allelic Composition	Ddit3^tm1Dron/Ddit3^tm1Dron Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0
Genetic Background	involves: 129X1/SvJ * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3^tm1Dron mutation (1 available); any Ddit3 mutation (20 available)
Tg(Col2a1-rtTA,tetO-COMP*)2Jath mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased inflammatory response ( J:233238 )

• doxycycline treated mice show decreased levels of inflammatory markers in the growth plate compared to Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0 mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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