Phenotypes associated with this allele

• Allele Symbol: Foxh1^tm1.1Hmd
• Allele Name: targeted mutation 1.1, Hiroshi Hamada
• Allele ID: MGI:2654232
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxh1^tm1Hmd/Foxh1^tm1.1Hmd Tg(Leftb-cre)1Hmd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6Cr	MGI:2654236

Genotype
MGI:2654236

cn1

• Allelic Composition: Foxh1^tm1Hmd/Foxh1^tm1.1Hmd; Tg(Leftb-cre)1Hmd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6Cr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:82311 )

• mutant mice die within several days after birth

growth/size/body

atrial situs inversus ( J:82311 )

• 30% of mutants display left-right inversion of the atrium

right-sided stomach ( J:82311 )

• 19% of mutants display the stomach on the right side of the body

right-sided isomerism ( J:82311 )

• mutant exhibit various left-right defects in the visceral organs, including the stomach

• both left and right lungs have four lobes (89%) or two or three lobes on the left side and four lobes on the right side (7%)

• the position of azygos vein, normally on the left side, is reversed (30%), bilateral (33%) or normal (37%)

• the position of the heart apex is reversed (toward the right; 37%), ambiguous (in the middle; 17%) or normal (toward the left; 46%)

• the relative positions of left and right renal veins are reversed (32%) or the two veins are located at the same level (27%)

• the atrium shows either right isomerism (26%) or left-right inversion (30%)

• the portal vein passes ventrally to the duodenum, instead of dorsally

right atrial isomerism ( J:82311 )

• 26% of mutants display right atrial isomerism

right pulmonary isomerism ( J:82311 )

• 89% of mutants exhibit right pulmonary isomerism, having four lobes on both sides

• 7% of mutants display partial right isomerism, having two or three lobes on the left side and four lobes on the right side

cardiovascular system

abnormal renal vein morphology ( J:82311 )

• the relative positions of left and right renal veins are reversed (32%) or the two veins are located at the same level (27%)

abnormal azygos vein morphology ( J:82311 )

• the position of azygos vein, normally on the left side, is reversed (30%), bilateral (33%) or normal (37%)

abnormal hepatic portal vein morphology ( J:82311 )

• the portal vein passes ventrally to the duodenum, instead of dorsally

double outlet right ventricle ( J:82311 )

• 76% of mutants display double-outlet right ventricle

transposition of great arteries ( J:82311 )

• 22% of mutants display transposition of the great arteries

atrial septal defect ( J:82311 )

• 73% of mutants exhibit atrial septal defects without valve defects

abnormal heart position or orientation ( J:82311 )

• the position of the heart apex is reversed (toward the right; 37%), ambiguous (in the middle; 17%) or normal (toward the left; 46%)

atrial situs inversus ( J:82311 )

• 30% of mutants display left-right inversion of the atrium

right atrial isomerism ( J:82311 )

• 26% of mutants display right atrial isomerism

dextrocardia ( J:82311 )

• the position of the heart apex is often reversed (toward the right; 37%)

mesocardia ( J:82311 )

• the position of the heart apex is sometimes ambiguous (in the middle; 17%)

complete atrioventricular septal defect ( J:82311 )

• 24% of mutants display endocardial cushion defects (common atrioventricular valve plus atrial septal defects and ventricular septal defects)

ventricular septal defect ( J:82311 )

• 61% of mutants display ventricular septal defects without valve defects

respiratory system

right pulmonary isomerism ( J:82311 )

• 89% of mutants exhibit right pulmonary isomerism, having four lobes on both sides

• 7% of mutants display partial right isomerism, having two or three lobes on the left side and four lobes on the right side

digestive/alimentary system

right-sided stomach ( J:82311 )

• 19% of mutants display the stomach on the right side of the body

hematopoietic system

spleen hypoplasia ( J:82311 )

• 53% of mutants display hypoplasia of the spleen

renal/urinary system

abnormal renal vein morphology ( J:82311 )

• the relative positions of left and right renal veins are reversed (32%) or the two veins are located at the same level (27%)

immune system

spleen hypoplasia ( J:82311 )

• 53% of mutants display hypoplasia of the spleen