Analysis Tools
mortality/aging
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• mutant mice die within several days after birth
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growth/size/body
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• 30% of mutants display left-right inversion of the atrium
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• 19% of mutants display the stomach on the right side of the body
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• mutant exhibit various left-right defects in the visceral organs, including the stomach
• both left and right lungs have four lobes (89%) or two or three lobes on the left side and four lobes on the right side (7%)
• the position of azygos vein, normally on the left side, is reversed (30%), bilateral (33%) or normal (37%)
• the position of the heart apex is reversed (toward the right; 37%), ambiguous (in the middle; 17%) or normal (toward the left; 46%)
• the relative positions of left and right renal veins are reversed (32%) or the two veins are located at the same level (27%)
• the atrium shows either right isomerism (26%) or left-right inversion (30%)
• the portal vein passes ventrally to the duodenum, instead of dorsally
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• 26% of mutants display right atrial isomerism
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• 89% of mutants exhibit right pulmonary isomerism, having four lobes on both sides
• 7% of mutants display partial right isomerism, having two or three lobes on the left side and four lobes on the right side
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cardiovascular system
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• the relative positions of left and right renal veins are reversed (32%) or the two veins are located at the same level (27%)
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• the position of azygos vein, normally on the left side, is reversed (30%), bilateral (33%) or normal (37%)
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• the portal vein passes ventrally to the duodenum, instead of dorsally
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• 76% of mutants display double-outlet right ventricle
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• 22% of mutants display transposition of the great arteries
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• 73% of mutants exhibit atrial septal defects without valve defects
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• the position of the heart apex is reversed (toward the right; 37%), ambiguous (in the middle; 17%) or normal (toward the left; 46%)
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• 30% of mutants display left-right inversion of the atrium
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• 26% of mutants display right atrial isomerism
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dextrocardia
(
J:82311
)
|
• the position of the heart apex is often reversed (toward the right; 37%)
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mesocardia
(
J:82311
)
|
• the position of the heart apex is sometimes ambiguous (in the middle; 17%)
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• 24% of mutants display endocardial cushion defects (common atrioventricular valve plus atrial septal defects and ventricular septal defects)
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• 61% of mutants display ventricular septal defects without valve defects
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respiratory system
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• 89% of mutants exhibit right pulmonary isomerism, having four lobes on both sides
• 7% of mutants display partial right isomerism, having two or three lobes on the left side and four lobes on the right side
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digestive/alimentary system
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• 19% of mutants display the stomach on the right side of the body
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hematopoietic system
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• 53% of mutants display hypoplasia of the spleen
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renal/urinary system
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• the relative positions of left and right renal veins are reversed (32%) or the two veins are located at the same level (27%)
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immune system
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• 53% of mutants display hypoplasia of the spleen
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