reproductive system
• intralumenal spaces in preputial glands are small
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• small reproductive gland
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vision/eye
• anterior eye chamber is not formed and the prospective chamber is occupied by pigmented cells
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• absent
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• the epithelial and mesenchymal cells are not clearly segregated in the cornea
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• the prospective cornea is thickened at E17
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• at E10.5, the lens placode fails to invaginate to form a lens vesicle
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• proliferation of the lens placode is impaired; at the 30-somite stage, number of BrdU labeled cells is reduced in the lens placode and at the 35 somite stage, BrdU-positive cells are rarely seen in the malformed lens placode
• at the 35-somite stage, significantly more TUNEL-positive cells are seen in the lens placode but not at the 32- or 40-somite stages, indicating an increase in apoptosis at this time
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• lens is not seen at E13, E16, and E17 and only a rudimentary lens is present in adults
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• malformation of the retina is seen at E13
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• the pigmented epithelium is malformed at E12.5 but not E10.5
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• retina is thickened at E17
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endocrine/exocrine glands
• intralumenal spaces in preputial glands are small
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• small reproductive gland
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renal/urinary system
• intralumenal spaces in preputial glands are small
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• small reproductive gland
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pigmentation
• the pigmented epithelium is malformed at E12.5 but not E10.5
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integument
• intralumenal spaces in preputial glands are small
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• small reproductive gland
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