Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Gnaq)25Gwd
• Allele Name: transgene insertion 25, Gerald W Dorn II
• Allele ID: MGI:2654360
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Fhl1^tm1Chen/Y Tg(Myh6-Gnaq)25Gwd/0	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N	MGI:3832664
cx2	Tg(Myh6-Gnaq)25Gwd/0 Tg(Myh6-Gnaq)40Gwd/0	involves: FVB/N	MGI:2654385
tg3	Tg(Myh6-Gnaq)25Gwd/0	involves: FVB/N	MGI:2654374

Genotype
MGI:3832664

cx1

• Allelic Composition: Fhl1^tm1Chen/Y; Tg(Myh6-Gnaq)25Gwd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:144736 )

♂N • cardiomyopathy induced by the expression of the transgene is rescued

Genotype
MGI:2654385

cx2

• Allelic Composition: Tg(Myh6-Gnaq)25Gwd/0; Tg(Myh6-Gnaq)40Gwd/0
• Genetic Background: involves: FVB/N

mortality/aging

premature death ( J:41949 )

cardiovascular system

enlarged heart ( J:41949 )

• massive enlargement and dilation of all four cardiac chambers

abnormal heart ventricle morphology ( J:41949 )

• ventricles show mild to moderate cellular edema with little or no myocyte loss

dilated cardiomyopathy ( J:41949 )

congestive heart failure ( J:41949 )

• spontaneous cardiac decompensation is seen in 3 of 6 double mutants

respiratory system

increased lung weight ( J:41949 )

• lung/body weight ratio averages 40% more than in controls

pleural effusion ( J:41949 )

• large bilateral pleural effusions

tachypnea ( J:41949 )

• 3 of 6 double mutants become tachypneic between 11 and 14 weeks of age

respiratory distress ( J:41949 )

• 3 of 6 double mutants develop severe respiratory distress between 11 and 14 weeks of age

muscle

dilated cardiomyopathy ( J:41949 )

homeostasis/metabolism

pleural effusion ( J:41949 )

• large bilateral pleural effusions

growth/size/body

enlarged heart ( J:41949 )

• massive enlargement and dilation of all four cardiac chambers

increased lung weight ( J:41949 )

• lung/body weight ratio averages 40% more than in controls

Genotype
MGI:2654374

tg3

• Allelic Composition: Tg(Myh6-Gnaq)25Gwd/0
• Genetic Background: involves: FVB/N

cardiovascular system

increased myocardial fiber size ( J:41949 )

thick interventricular septum ( J:144736 )

• mice exhibit an increased interventricular septal thickness compared to in wild-type mice

cardiac hypertrophy ( J:41949 )

• heart weight is 25% greater than in controls and cardiomyocyte dimensions are larger

abnormal heart left ventricle morphology ( J:144736 )

• mice exhibit an increase in left ventricle posterior wall thickness compared to in wild-type mice

heart left ventricle hypertrophy ( J:41949 )

decreased cardiac muscle contractility ( J:41949 , J:144736 )

• fractional shortening is depressed (J:41949)

• the normal beta-adrenergic (via dobutamine) augmentation of cardiac contractility and relaxation is absent in mutants (J:41949)

decreased heart left ventricle muscle contractility ( J:41949 )

• reduction in contractility of left ventricle

increased left ventricle diastolic pressure ( J:144736 )

decreased heart rate ( J:41949 )

• heart rate is slower during conscious blood pressure measurements and anesthetized echocardiographic studies

decreased systemic arterial systolic blood pressure ( J:41949 )

muscle

increased myocardial fiber size ( J:41949 )

heart left ventricle hypertrophy ( J:41949 )

decreased cardiac muscle contractility ( J:41949 , J:144736 )

• fractional shortening is depressed (J:41949)

• the normal beta-adrenergic (via dobutamine) augmentation of cardiac contractility and relaxation is absent in mutants (J:41949)

decreased heart left ventricle muscle contractility ( J:41949 )

• reduction in contractility of left ventricle

growth/size/body

cardiac hypertrophy ( J:41949 )

• heart weight is 25% greater than in controls and cardiomyocyte dimensions are larger

heart left ventricle hypertrophy ( J:41949 )