All Phenotypes Tg(Myh6-Gnaq)40Gwd MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:41949 )

cardiovascular system

enlarged heart ( J:41949 )

• massive enlargement and dilation of all four cardiac chambers

• ventricles show mild to moderate cellular edema with little or no myocyte loss

dilated cardiomyopathy ( J:41949 )

congestive heart failure ( J:41949 )

• spontaneous cardiac decompensation is seen in 3 of 6 double mutants

respiratory system

increased lung weight ( J:41949 )

• lung/body weight ratio averages 40% more than in controls

pleural effusion ( J:41949 )

• large bilateral pleural effusions

tachypnea ( J:41949 )

• 3 of 6 double mutants become tachypneic between 11 and 14 weeks of age

respiratory distress ( J:41949 )

• 3 of 6 double mutants develop severe respiratory distress between 11 and 14 weeks of age

muscle

dilated cardiomyopathy ( J:41949 )

homeostasis/metabolism

pleural effusion ( J:41949 )

• large bilateral pleural effusions

growth/size/body

enlarged heart ( J:41949 )

• massive enlargement and dilation of all four cardiac chambers

increased lung weight ( J:41949 )

• lung/body weight ratio averages 40% more than in controls

Allelic Composition	Tg(Myh6-Gnaq)40Gwd/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Gnaq)40Gwd mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:41949 )

• most die by 5 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congestive heart failure		DOID:6000		J:41949

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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