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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epha4tm1Kldr
targeted mutation 1, Klas Kullander
MGI:2654411
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epha4tm1Kldr/Epha4tm1Kldr involves: 129S/SvEv * C57BL/6 MGI:3608667
hm2
 		Epha4tm1Kldr/Epha4tm1Kldr Not Specified MGI:2654426
ht3
 		Epha4Gt(PST038)Byg/Epha4tm1Kldr involves: 129P2/OlaHsd MGI:3823255


Genotype
MGI:3608667
hm1
Allelic
Composition		 Epha4tm1Kldr/Epha4tm1Kldr
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm1Kldr mutation (0 available); any Epha4 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal anterior commissure morphology ( J:101019 )
• both the anterior and posterior limbs of the anterior commissure fail to cross the midline
ectopic thalamus ( J:101019 )
• in 43% of homozygotes thalamic neurons are located more medially than in wild-type mice
abnormal spinal cord dorsal column morphology ( J:101019 )
• the dorsoventral extent of the dorsal funiculus is reduced and fibers within the dorsal funiculus re-cross the midline at the lumbar level
abnormal central pattern generator function ( J:101019 )
• bilateral lumbar 2 and 5 ventral roots display synchronous rather than alternating bursts in most homozygotes




Genotype
MGI:2654426
hm2
Allelic
Composition		 Epha4tm1Kldr/Epha4tm1Kldr
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm1Kldr mutation (0 available); any Epha4 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:82479 )
• rabbit like gait

nervous system
abnormal motor neuron innervation pattern ( J:82479 )
• corticospinal tract nerve fibers aberrantly cross the spinal cord midline to the contralateral side
abnormal corticospinal tract morphology ( J:82479 )
• corticospinal tract nerve fibers aberrantly cross the spinal cord midline to the contralateral side
abnormal central pattern generator function ( J:82479 )
• abnormal excitation of central pattern generators
• lumbar segments of the spinal cords of neonates exhibit synchronous left-right ventral root activity instead of the left-right alternating activity observed in wild-type after NMDA and serotonin application
• the abnormal synchronous activity can be converted to the normal alternation by antagonists of inhibitory neurotransmitters such as sarcosine




Genotype
MGI:3823255
ht3
Allelic
Composition		 Epha4Gt(PST038)Byg/Epha4tm1Kldr
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4Gt(PST038)Byg mutation (1 available); any Epha4 mutation (67 available)
Epha4tm1Kldr mutation (0 available); any Epha4 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron innervation pattern ( J:82479 )
• spinal cord neurons that normally express Epha4 aberrantly cross the spinal cord midline to the contralateral side
abnormal corticospinal tract morphology ( J:82479 )
• spinal cord neurons that normally express Epha4 aberrantly cross the spinal cord midline to the contralateral side




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory