Phenotypes associated with this allele

• Allele Symbol: Rr308^tm1.1Fwa
• Allele Name: targeted mutation 1.1, Frederick W Alt
• Allele ID: MGI:2654436
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr308^tm1.1Fwa/Rr308^tm1.1Fwa	involves: 129P2/OlaHsd	MGI:2654485

Genotype
MGI:2654485

hm1

• Allelic Composition: Rr308^tm1.1Fwa/Rr308^tm1.1Fwa
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:82395 , J:82616 )

• alpha beta T cell development is blocked at the double postive thymocyte stage; thymocytes express very low levels of TCRbeta and majority of T cells express TCRalpha chains that utilize Valpha2 family gene segments (J:82616)

abnormal T cell receptor alpha chain V-J recombination ( J:82616 )

• block in V alpha/J alpha50 recombination

immune system

abnormal T cell differentiation ( J:82395 , J:82616 )

• alpha beta T cell development is blocked at the double postive thymocyte stage; thymocytes express very low levels of TCRbeta and majority of T cells express TCRalpha chains that utilize Valpha2 family gene segments (J:82616)

abnormal T cell receptor alpha chain V-J recombination ( J:82616 )

• block in V alpha/J alpha50 recombination