Phenotypes associated with this allele

• Allele Symbol: Npy2r^tm1Pern
• Allele Name: targeted mutation 1, Patrick Ernfors
• Allele ID: MGI:2654580
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npy2r^tm1Pern/Npy2r^tm1Pern	involves: 129	MGI:3763740
hm2	Npy2r^tm1Pern/Npy2r^tm1Pern	involves: 129/Sv * BALB/c	MGI:2654595
hm3	Npy2r^tm1Pern/Npy2r^tm1Pern	involves: 129/Sv * BALB/cJ	MGI:3722260
cx4	Npy1r^tm1Pern/Npy1r^tm1Pern Npy2r^tm1Pern/Npy2r^tm1Pern	involves: 129	MGI:3763741
cx5	Lep^ob/Lep^ob Npy2r^tm1Pern/Npy2r^tm1Pern	involves: 129 * BALB/c * C57BL/10J	MGI:3722276
cx6	Npy2r^tm1Pern/Npy2r^tm1Pern Npy5r^tm1Pern/Npy5r^tm1Pern	involves: 129/Sv * BALB/c	MGI:3763739

Genotype
MGI:3763740

hm1

• Allelic Composition: Npy2r^tm1Pern/Npy2r^tm1Pern
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal righting response ( J:71826 )

• 50 mg/kg and 60 mg/kg of sodium pentobarbital induces a greater loss of righting reflex (LORR) than in wild-type mice (135% and143%, respectively by dose)

• however, righting response is no different from that of wild-type mice after treatment with ketamin

• NPY-induced sensitization to LORR induced by pentobarbital or ketamine is increased compared to in wild-type mice

• NPY-induced sensitization to LORR induced by pentobarbital greater when NPY is injected into the posterior hypothalamus versus the lateral hypothalamus

abnormal sleep duration ( J:71826 )

• mice sleep longer than wild-type mice following treatment with pentobarbital

Genotype
MGI:2654595

hm2

• Allelic Composition: Npy2r^tm1Pern/Npy2r^tm1Pern
• Genetic Background: involves: 129/Sv * BALB/c

adipose tissue

increased total fat pad weight ( J:57961 )

behavior/neurological

polyphagia ( J:57961 )

• mean 12% increase in 24-hour food consumption

decreased locomotor activity ( J:57961 )

• reduction in activity during both dark and light phases

cardiovascular system

abnormal circadian regulation of heart rate ( J:57961 )

• increase shows statistical significance at night

growth/size/body

increased body weight ( J:57961 )

• males and females fed a normal-fat diet are mildly overweight

• a high-fat diet leads to a more substantial increase in body weight, especially in females

homeostasis/metabolism

decreased energy expenditure ( J:57961 )

• reduction in energy consumption as indicated by reduced activity during both light and dark phases

decreased response to leptin ( J:57961 )

• mutants show an attenuated response to leptin, exhibiting only a 15.2% reduction in food intake compared to 30.5% decrease in wild-type mice, 12 hours after leptin administration, however no differences in food intake are observed after 45 hours

Genotype
MGI:3722260

hm3

• Allelic Composition: Npy2r^tm1Pern/Npy2r^tm1Pern
• Genetic Background: involves: 129/Sv * BALB/cJ

behavior/neurological

alcohol aversion ( J:102430 )

• mice drink less 3% and 6% ethanol solution than wild-type mice

increased fluid intake ( J:102430 )

• water consumption is increased relative to wild-type mice

Genotype
MGI:3763741

cx4

• Allelic Composition: Npy1r^tm1Pern/Npy1r^tm1Pern; Npy2r^tm1Pern/Npy2r^tm1Pern
• Genetic Background: involves: 129

behavior/neurological

abnormal righting response ( J:71826 )

• authors state that mice display a similar sensitivity to loss of righting response induced by pentobarbital as Npy1r^tm1Pern homozygous mice

• mice display a decrease in loss of righting response to ketamin-sedation compared to wild-type mice

Genotype
MGI:3722276

cx5

• Allelic Composition: Lep^ob/Lep^ob; Npy2r^tm1Pern/Npy2r^tm1Pern
• Genetic Background: involves: 129 * BALB/c * C57BL/10J

homeostasis/metabolism

decreased circulating glucose level ( J:102651 )

• mice have reduced glucose levels relative to in Lep^ob homozygotes but similar to in wild-type mice

decreased circulating LDL cholesterol level ( J:102651 )

• LDL levels are decreased by 58% relative to in Lep^ob homozygotes

increased circulating cholesterol level ( J:102651 )

• mice exhibit hypercholesterolemia relative to wild-type mice that is not as severe as in Lep^ob homozygotes

increased circulating HDL cholesterol level ( J:102651 )

• mice exhibit an increase in HDL relative to wild-type mice similar to in Lep^ob homozygotes

decreased circulating free fatty acids level ( J:102651 )

• free fatty acid levels are decreased relative to Lep^ob homozygotes and heterozygotes

increased triglyceride level ( J:102651 )

• mice exhibit an increase triglyceride levels relative to wild-type mice but similar to in Lep^ob homozygotes

growth/size/body

decreased body weight ( J:102651 )

• starting at week 9, female mice weigh less than Lep^ob homozygotes

Genotype
MGI:3763739

cx6

• Allelic Composition: Npy2r^tm1Pern/Npy2r^tm1Pern; Npy5r^tm1Pern/Npy5r^tm1Pern
• Genetic Background: involves: 129/Sv * BALB/c

behavior/neurological

behavior/neurological phenotype ( J:71826 )

N • impaired righting response caused by pentobarbital or ketamin is the same as in wild-type mice