Phenotypes associated with this allele

• Allele Symbol: Cxxc1^tm1Skk
• Allele Name: targeted mutation 1, David G Skalnik
• Allele ID: MGI:2654854
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxxc1^tm1Skk/Cxxc1^tm1Skk	involves: 129S/SvEv * C57BL/6	MGI:2654859

Genotype
MGI:2654859

hm1

• Allelic Composition: Cxxc1^tm1Skk/Cxxc1^tm1Skk
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:72634 )

• homozygous mutant embryos die between E3.5 and E6.5

• no embryos are detected between E6.5 and E12.5

• however, in vitro, mutant blastocysts are viable and capable of hatching and forming both an inner cell mass and a trophectoderm

embryo

failure to gastrulate ( J:72634 )

• at E6.5, presumptive mutant embryos fail to display both the embryonic ectoderm and the embryonic endoderm and appear as a small mass of pyknotic cells

absent embryonic epiblast ( J:72634 )

• the embryonic ectoderm is not present at E6.5

absent endoderm ( J:72634 )

• the embryonic endoderm is not present at E6.5

abnormal ectoplacental cone morphology ( J:72634 )

• a region resembling the ectoplacental cone is detectable but lacks the typical cobblestone appearance at E6.5

reproductive system

empty decidua capsularis ( J:72634 )

• only empty decidua with embryo remnants are present at E6.5