Phenotypes associated with this allele

• Allele Symbol: Bcl2l1^tm1Tak
• Allele Name: targeted mutation 1, Junji Takeda
• Allele ID: MGI:2654939
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bcl2l1^tm1Tak/Bcl2l1^tm1Tak Tg(KRT5-cre)1Tak/0	involves: C3H * C57BL/6	MGI:2654940

Genotype
MGI:2654940

cn1

• Allelic Composition: Bcl2l1^tm1Tak/Bcl2l1^tm1Tak; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased keratinocyte adhesion ( J:82661 )

• attachment of isolated keratinocytes to dishes is reduced to about 70% of that of wild-type

increased cellular sensitivity to ultraviolet irradiation ( J:82661 )

• topical application of wortmannin sensitizes the mutant, but not wild-type, skin to UVB-induced apoptosis

increased keratinocyte apoptosis ( J:82661 )

• increase in the number of apoptotic cells in the epidermis

• keratinocytes cultured in vitro exhibit increased incidence of apoptosis in the absence of growth factors

• however, addition of growth factors such as hepatocyte growth factor attenuates the apoptosis

integument

decreased keratinocyte adhesion ( J:82661 )

• attachment of isolated keratinocytes to dishes is reduced to about 70% of that of wild-type

increased keratinocyte apoptosis ( J:82661 )

• increase in the number of apoptotic cells in the epidermis

• keratinocytes cultured in vitro exhibit increased incidence of apoptosis in the absence of growth factors

• however, addition of growth factors such as hepatocyte growth factor attenuates the apoptosis