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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nodaltm1Hmd
targeted mutation 1, Hiroshi Hamada
MGI:2654943
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nodaltm1Hmd/Nodaltm1Hmd either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ) MGI:2654944
cx2
 		Nodaltm1Hmd/Nodal+
Tg(Rr443-Lefty1,-lacZ)36Hmd/0 		either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ) MGI:2654949


Genotype
MGI:2654944
hm1
Allelic
Composition		 Nodaltm1Hmd/Nodaltm1Hmd
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm1Hmd mutation (1 available); any Nodal mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:82703 )
• 75% of embryos survive until birth but die immediately at or within a few hours after birth
embryonic lethality during organogenesis, incomplete penetrance ( J:82703 )
• 25% of embryos are arrested at midgestation, around E13, while the rest develop to term

growth/size/body
right-sided isomerism ( J:82703 )
• right isomerism of the heart and lungs
right atrial isomerism ( J:82703 )
• both atria of heart resembles the right atrium
right pulmonary isomerism ( J:82703 )
• both the left and right lungs of mutants have four lobes

cardiovascular system
transposition of great arteries ( J:82703 )
• reversed position of the great arteries
abnormal heart position or orientation ( J:82703 )
• random orientation of the heart apex to the left, right, or middle
right atrial isomerism ( J:82703 )
• both atria of heart resembles the right atrium

embryo
abnormal left-right axis patterning ( J:82703 )
• internal organs exhibit right-sided isomerism
embryonic growth arrest ( J:82703 )
• approximately 25% of homozygotes arrest at midgestation, around E13

hematopoietic system
abnormal spleen morphology ( J:82703 )
• mutants exhibit several punctate spleens or one small spleen

immune system
abnormal spleen morphology ( J:82703 )
• mutants exhibit several punctate spleens or one small spleen

liver/biliary system
abnormal liver morphology ( J:82703 )
• abnormal liver lobation, including clefts in the medial lobes

respiratory system
right pulmonary isomerism ( J:82703 )
• both the left and right lungs of mutants have four lobes

digestive/alimentary system
abnormal stomach position or orientation ( J:82703 )
• random rotation of the stomach
abnormal digestive system development ( J:82703 )
• disorganization of gut coiling




Genotype
MGI:2654949
cx2
Allelic
Composition		 Nodaltm1Hmd/Nodal+
Tg(Rr443-Lefty1,-lacZ)36Hmd/0
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm1Hmd mutation (1 available); any Nodal mutation (42 available)
Tg(Rr443-Lefty1,-lacZ)36Hmd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:82703 )
• positions of the great arteries are disorganized
right atrial isomerism ( J:82703 )
• both atria of heart resembles the right atrium
dextrocardia ( J:82703 )
• the apex of the heart is oriented to the right

growth/size/body
right-sided isomerism ( J:82703 )
• right isomerism of the heart and lungs
right atrial isomerism ( J:82703 )
• both atria of heart resembles the right atrium
right pulmonary isomerism ( J:82703 )
• 1/3 mice exhibit three lobes in the left lung and four lobes in the right lung, while the other 2/3 mice show typical right isomerism of the lung

embryo
abnormal left-right axis patterning ( J:82703 )
• left-right isomerism of some internal organs

hematopoietic system
small spleen ( J:82703 )
• spleen is positioned normally but is smaller in size

respiratory system
right pulmonary isomerism ( J:82703 )
• 1/3 mice exhibit three lobes in the left lung and four lobes in the right lung, while the other 2/3 mice show typical right isomerism of the lung

digestive/alimentary system
abnormal digestive system development ( J:82703 )
• gut looping is incomplete

liver/biliary system
abnormal liver morphology ( J:82703 )
• clefts in the medial lobes of the liver

immune system
small spleen ( J:82703 )
• spleen is positioned normally but is smaller in size




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory