Phenotypes associated with this allele

• Allele Symbol: Tg(Krt1-14-GLI)1Oro
• Allele Name: transgene insertion 1, Anthony E Oro
• Allele ID: MGI:2655200
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Krt1-14-GLI)1Oro/0	involves: C57BL/6 * CBA	MGI:2655222

Genotype
MGI:2655222

tg1

• Allelic Composition: Tg(Krt1-14-GLI)1Oro/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:82653 )

• die by 5 months of age from skin infections

neoplasm

increased tumor incidence ( J:82653 )

• 75% of epithelial proliferations differentiate into cells similar to sebaceous glands and epidermal cysts

increased trichofolliculoma incidence ( J:82653 )

• epithelial invaginations form tumors with various characteristics of the hair follicle lineage with 25% of epithelial proliferations resembling trichoepitheliomas

• tumors form during the anagen phase of the hair cycle

• they are neither mature, well-differentiated hair follicles nor basal cell carcinomas

integument

alopecia ( J:82653 )

• mice begin to lose their hair at around postnatal day 26, at the onset of anagen

spontaneous skin ulceration ( J:82653 )

• skin gradually develops small ulcers after P26

increased trichofolliculoma incidence ( J:82653 )

• epithelial invaginations form tumors with various characteristics of the hair follicle lineage with 25% of epithelial proliferations resembling trichoepitheliomas

• tumors form during the anagen phase of the hair cycle

• they are neither mature, well-differentiated hair follicles nor basal cell carcinomas