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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Grin1tm2Slab
targeted mutation 2, Ralf Schoepfer
MGI:2655237
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Grin1tm2Slab/Grin1tm1.1Slab involves: 129P2/OlaHsd * C57BL/6J MGI:2655238


Genotype
MGI:2655238
ht1
Allelic
Composition
Grin1tm2Slab/Grin1tm1.1Slab
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1.1Slab mutation (0 available); any Grin1 mutation (67 available)
Grin1tm2Slab mutation (2 available); any Grin1 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice died within 1 hour of birth

homeostasis/metabolism

respiratory system

nervous system
• absence of whisker-related patterning in the brainstem trigeminal complex
• however, no difference is seen between external brain morphology or weight relative to control mice
• absence of patterned synapses of trigeminal afferents and their target cells (barrelettes)
• normal topographic mapping of primary trigeminal afferents
• NMDA receptors are functional but lack coincidence detection properties





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory