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Allele Symbol Allele Name Allele ID |
Kdrtm1(cre)Sato targeted mutation 1, Thomas N Sato MGI:2655253 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike single Wnk1 homozygotes, heart morphology is grossly normal
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• the incidence of abnormal embryos is increased compared to controls indicating only a partial rescue
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die between E9.5 and E10.5
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• all exhibit angiogenesis defects as only the primary vascular plexus is observed in E9.5 and E10.5 yolk sacs
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• the number of hematopoietic colonies in a hematopoietic progenitor assay at E8.5 is decreased by about 50%
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• all exhibit angiogenesis defects as only the primary vascular plexus is observed in E9.5 and E10.5 yolk sacs
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• trabeculae in the ventricles is much thinner at E9.5
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• the atrioventricular canal endocardial cushion is absent
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• the number of hematopoietic colonies in a hematopoietic progenitor assay at E8.5 is decreased by about 50%
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• trabeculae in the ventricles is much thinner at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die between E10.5 and E11.5
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• E10.5 yolk sacs show only the primary vascular plexus of poorly developed vascular channels instead of large vessels with extensive branching and well-developed capillary network
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• fail to develop beyond E11.5 as indicated by the small size and failure to form digits at E12.5
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• 21 of 69 exhibit pale yolk sacs at E10.5 and by E11.5, all mutants have pale yolk sacs
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• exhibit defective vessel development
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• often show abnormal branching in the trunk
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• E10.5 yolk sacs show only the primary vascular plexus of poorly developed vascular channels instead of large vessels with extensive branching and well-developed capillary network
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• exhibit fewer smooth muscle cell numbers around the dorsal aortas and those that are present do not make close contacts with adjacent endothelial cells
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• often show dilated vessels in the brain
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• at E10.5, the atrioventricular canal endocardial cushion is absent, however the development of the outflow tract cushion appears normal
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• cavity between the pericardial sac and the heart is distended
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• all mutants exhibit hemorrhage throughout the trunk region of the embryo at E11.5
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• embryos surviving to E11.5 are morphologically normal at E10.5 but subsequently succumb to death displaying abdominal hemorrhage
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• exhibit fewer smooth muscle cell numbers around the dorsal aortas and those that are present do not make close contacts with adjacent endothelial cells
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| N |
• exhibit normal embryonic and definitive hematopoiesis
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• cavity between the pericardial sac and the heart is distended
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• at E12.5, embryos are totally pale, although some of them still have red fluid within the amnion
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all embryos die by E12.5 due to severe hemorrhaging within the central nervous system
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• in E12.5 embryos, endothelial cells and pericytes are entirely absent from the neuroepithelium
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• hemorrhaging is detected throughout the developing brain of E12.5 embryos
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• hemorrhaging is detected throughout the developing spine of E12.5 embryos
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• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos
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• hemorrhaging is detected throughout the developing brain of E12.5 embryos
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• hemorrhaging is detected throughout the developing spine of E12.5 embryos
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• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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