About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Grid2ho-Nancy
hotfoot Nancy
MGI:2655335
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Grid2ho-Nancy/Grid2ho-Nancy involves: C57BL/6 MGI:2655338
ht2
Grid2Lc/Grid2ho-Nancy involves: C57BL/6 * STOCK MitfMi-wh MGI:2655345


Genotype
MGI:2655338
hm1
Allelic
Composition
Grid2ho-Nancy/Grid2ho-Nancy
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grid2ho-Nancy mutation (0 available); any Grid2 mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in non-rotating rod test, equilibrium times of mutants are lower than controls in all three trials (J:82371)
• mutants fall often, generally after rearing up or grooming, during the period of hyperactivity in response to stimulus (J:82709)
• mutants exhibit poor performance in a motor training test with a rotarod, however they are able to improve their performance over time
• body is flattened to the ground while walking
• tapping of the hindpaws; phenotype is much more severe than in Grid2ho-4J mice
• mutants exhibit increased stumbling frequency in a motor coordination test
• jumpy, hopping gait; hindlimbs are alternately raised very rapidly
• the angle of the feet is more open in mutants than controls
• mutants exhibit a reduction in the length of stride by at least half due to mutants moving the same hind foot forward very rapidly, several times in succession, by a very small distance each time, advancing the contralateral foot
• adults often walk backwards
• upon pressure on the tail, mutants back up or turn around and vocalize instead of running away as do controls
• when flanks are pressed, mutants leap forward powerfully
• some mice when lifted by the tail, pull their hind feet together up to the belly

nervous system
• Purkinje cells have ectopic spines devoid of presynaptic innervations (J:82371)
• occurrence of long ectopic and sometimes branching spines emanating from the proximal dendritic compartment of Purkinje cells (J:82371)
• ectopic spines are frequently innervated by parallel fiber varicosities (J:82371)
• presence of non-innervated (naked) spines in the vicinity of Purkinje cell dendrites (J:82371)
• occasional occurrence of pyknotic nuclei in the granule cell layer (J:82371)
• slight atrophy of the granule layer (J:82709)
• slight atrophy of the molecular layer
• the molecular layer exhibits atypical axon terminals, with hypertrophy of the smooth endoplasmic reticulum
• cerebellum is slightly reduced in size
• slight atrophy of the granule and molecular layers
• although most Purkinje cells are innervated by a single climbing fiber, about 19-20% of cells show innervation by more than one climbing fiber
• mismatching between the length of the presynaptic active zones, in parallel fiber varicosities, and the postsynaptic differentiations in Purkinje cell dendritic spines (J:82371)
• some somatodendritic synapses occur between the perikarya of basket or stellate cells and Purkinje cell dendritic spines or small dendritic profiles (J:82371)




Genotype
MGI:2655345
ht2
Allelic
Composition
Grid2Lc/Grid2ho-Nancy
Genetic
Background
involves: C57BL/6 * STOCK MitfMi-wh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grid2ho-Nancy mutation (0 available); any Grid2 mutation (85 available)
Grid2Lc mutation (2 available); any Grid2 mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

nervous system
• the P0 cerebellum is less developed than in the control
• decreased foliation at P5
• external granule cell layer are almost completely absent at P10 and thickness is reduced at P5
• depolarization of Purkinje cells is detected at P9 but not earlier; holding currents are significantly larger at P9-P12
• autophagy is detected in P5 Purkinje cells
• Purkinje cell degeneration by P5 that is not correlated with depolarization in the cerebellum (first observed at P9)
• internal granule cell layer is almost completely absent at P10 and thickness is reduced at P5
• cerebellum is atrophic at P21

cellular
• autophagy is detected in P5 Purkinje cells

homeostasis/metabolism
• autophagy is detected in P5 Purkinje cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory