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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lck-cre)3785Nik
transgene insertion 3785, Nigel Killeen
MGI:2655481
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd4tm1Litt/Cd4tm1Nik
Tg(Lck-cre)3785Nik/0 		involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 MGI:2655530


Genotype
MGI:2655530
cn1
Allelic
Composition		 Cd4tm1Litt/Cd4tm1Nik
Tg(Lck-cre)3785Nik/0
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Litt mutation (4 available); any Cd4 mutation (85 available)
Cd4tm1Nik mutation (2 available); any Cd4 mutation (85 available)
Tg(Lck-cre)3785Nik mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell apoptosis ( J:73479 )
• increase in apoptosis of CD4 lineage T cells
increased T cell proliferation ( J:73479 )
• increase in proliferation of peripheral CD4 lineage cells
decreased CD4-positive, alpha-beta T cell number ( J:73479 )
• few peripheral CD4 lineage T cells
increased CD8-positive, alpha-beta T cell number ( J:73479 )
• increase in CD8+ T cells in lymph nodes
abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )
• CD4 lineage T cells exhibit an increase in proliferation and apoptosis

hematopoietic system
increased T cell apoptosis ( J:73479 )
• increase in apoptosis of CD4 lineage T cells
increased T cell proliferation ( J:73479 )
• increase in proliferation of peripheral CD4 lineage cells
decreased CD4-positive, alpha-beta T cell number ( J:73479 )
• few peripheral CD4 lineage T cells
increased CD8-positive, alpha-beta T cell number ( J:73479 )
• increase in CD8+ T cells in lymph nodes
abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )
• CD4 lineage T cells exhibit an increase in proliferation and apoptosis

cellular
increased T cell apoptosis ( J:73479 )
• increase in apoptosis of CD4 lineage T cells
increased T cell proliferation ( J:73479 )
• increase in proliferation of peripheral CD4 lineage cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory