Phenotypes associated with this allele

• Allele Symbol: Fn1^tm1Feb
• Allele Name: targeted mutation 1, Francisco E Baralle
• Allele ID: MGI:2655527
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fn1^tm1Feb/Fn1^tm1Feb	involves: 129X1/SvJ	MGI:2668713

Genotype
MGI:2668713

hm1

• Allelic Composition: Fn1^tm1Feb/Fn1^tm1Feb
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84274 )

• homozygotes develop normally and are phenotypically indistinguishable from wild-type mice; however, 90% of homozygotes die by 30 months of age

• no significant reduction in survival is observed up to 15 months of age

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:84274 )

N • homozygotes exhibit normal wound healing after full thickness cutaneous wounding, unlike Fn1^tm2Feb mutant mice

abnormal protein level ( J:84274 )

• adult homozygotes, but not embryos or prepubertal homozygotes, display a striking reduction of fibronectin levels in most tissues examined

• this decrease reaches a plateau at 2 months of age but does not correlate to changes neither in fibronectin mRNA nor in integrin levels

• in some tissues (heart, blood, brain, kidney, and diaphragm), fibronectin levels are only ~10-20% of wild-type levels

• in liver, fibronectin levels are 60%-70% of wild-type levels

• a significant decrease in fibronectin levels is also noted in plasma and serum samples

reproductive system

reproductive system phenotype ( J:84274 )

N • both male and female homozygotes are fertile