normal phenotype
• mice are viable, fertile and develop normally; normal formation and maintenance of skeletal elements; normal clinical-chemical parameters
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Allele Symbol Allele Name Allele ID |
Anxa5tm1Epo targeted mutation 1, Ernst Poeschl MGI:2655676 |
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Summary |
4 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are viable, fertile and develop normally; normal formation and maintenance of skeletal elements; normal clinical-chemical parameters
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• LPS-activated peritoneal macrophages show higher secretion of IL-10 than wild-type macrophages in response to mechanical stress-induced necrotic cells
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• mutant macrophages show a more anti-inflammatory and immunosuppressive potential in response to mechanical stress-induced necrotic cells
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• mutants do not show an allogeneic reaction against cells necrotized by mechanical stress, whereas wild-type mice show a strong reaction
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• decreased CD11c+ dendritic cells at 1 year in female mice
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• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
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• CD4+/CD8- T-helper cells at 1 year in the spleen
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• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice
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• with increased cell numbers
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• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice
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• decreased CD11c+ dendritic cells at 1 year in female mice
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• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
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• CD4+/CD8- T-helper cells at 1 year in the spleen
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• decreased CD11c+ dendritic cells at 1 year in female mice
|
|
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
|
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• decreased CD11c+ dendritic cells at 1 year in female mice
|
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• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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