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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Anxa5tm1Epo
targeted mutation 1, Ernst Poeschl
MGI:2655676
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Anxa5tm1Epo/Anxa5tm1Epo involves: 129 * C57BL/6 MGI:2655685
hm2
 		Anxa5tm1Epo/Anxa5tm1Epo involves: 129P2/OlaHsd * C57BL/6 MGI:3696683
cx3
 		Anxa5tm1Epo/Anxa5tm1Epo
Anxa6tm1Moss/Anxa6tm1Moss
Col10a1tm1Ksec/Col10a1tm1Ksec 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:5696128
cx4
 		Anxa5tm1Epo/Anxa5tm1Epo
Anxa6tm1Moss/Anxa6tm1Moss 		involves: 129P2/OlaHsd * C57BL/6 MGI:5696127


Genotype
MGI:2655685
hm1
Allelic
Composition		 Anxa5tm1Epo/Anxa5tm1Epo
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation (0 available); any Anxa5 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:82739 )
• mice are viable, fertile and develop normally; normal formation and maintenance of skeletal elements; normal clinical-chemical parameters




Genotype
MGI:3696683
hm2
Allelic
Composition		 Anxa5tm1Epo/Anxa5tm1Epo
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation (0 available); any Anxa5 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:117249 )
• LPS-activated peritoneal macrophages show higher secretion of IL-10 than wild-type macrophages in response to mechanical stress-induced necrotic cells
abnormal inflammatory response ( J:117249 )
• mutant macrophages show a more anti-inflammatory and immunosuppressive potential in response to mechanical stress-induced necrotic cells
decreased susceptibility to type IV hypersensitivity reaction ( J:117249 )
• mutants do not show an allogeneic reaction against cells necrotized by mechanical stress, whereas wild-type mice show a strong reaction




Genotype
MGI:5696128
cx3
Allelic
Composition		 Anxa5tm1Epo/Anxa5tm1Epo
Anxa6tm1Moss/Anxa6tm1Moss
Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation (0 available); any Anxa5 mutation (24 available)
Anxa6tm1Moss mutation (2 available); any Anxa6 mutation (42 available)
Col10a1tm1Ksec mutation (0 available); any Col10a1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased dendritic cell number ( J:193886 )
• decreased CD11c+ dendritic cells at 1 year in female mice
increased B cell number ( J:193886 )
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
increased T-helper cell number ( J:193886 )
• CD4+/CD8- T-helper cells at 1 year in the spleen

skeleton
abnormal femur morphology ( J:193886 )
• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice
increased width of hypertrophic chondrocyte zone ( J:193886 )
• with increased cell numbers

limbs/digits/tail
abnormal femur morphology ( J:193886 )
• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice

hematopoietic system
decreased dendritic cell number ( J:193886 )
• decreased CD11c+ dendritic cells at 1 year in female mice
increased B cell number ( J:193886 )
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
increased T-helper cell number ( J:193886 )
• CD4+/CD8- T-helper cells at 1 year in the spleen




Genotype
MGI:5696127
cx4
Allelic
Composition		 Anxa5tm1Epo/Anxa5tm1Epo
Anxa6tm1Moss/Anxa6tm1Moss
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation (0 available); any Anxa5 mutation (24 available)
Anxa6tm1Moss mutation (2 available); any Anxa6 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased dendritic cell number ( J:193886 )
• decreased CD11c+ dendritic cells at 1 year in female mice
increased B cell number ( J:193886 )
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age

hematopoietic system
decreased dendritic cell number ( J:193886 )
• decreased CD11c+ dendritic cells at 1 year in female mice
increased B cell number ( J:193886 )
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory