• injection of ISO (10 mg/kg) followed by a 20 min period of exercise on the treadmill significantly reduces the latency of heterozygotes to fall from the accelerating rotarod by ~15 sec, whereas wild-type mice remain unaffected
• a higher dose of ISO (20 mg/kg) followed exercise reduces the latency of heterozygotes to fall to a similar degree, whereas wild-type mice are only moderately affected
• injection of ISO (10 mg/kg) followed by exercise significantly increases the number of hindfoot missteps on the balance beam in heterozygotes, but has little effect on wild-type littermates
• injection of acetazolamide (AZT), a carbonic anhydrase inhibitor, at 10 min prior to ISO injection (20 mg/kg) followed by exercise abolishes the reduction in latency to fall from the accelerating rotarod in heterozygous mice
• similalry, ATZ significantly decreases the number of hindfoot missteps on the balance beam, induced by ISO and exercise in heterozygous mice