About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Camk2atm1Vyb
targeted mutation 1, Vadim Y Bolshakov
MGI:2655688
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Camk2atm1Vyb/Camk2atm1Vyb
Tg(Grik4-cre)G32-4Stl/0 		involves: C57BL/6 MGI:2655692


Genotype
MGI:2655692
cn1
Allelic
Composition		 Camk2atm1Vyb/Camk2atm1Vyb
Tg(Grik4-cre)G32-4Stl/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camk2atm1Vyb mutation (1 available); any Camk2a mutation (135 available)
Tg(Grik4-cre)G32-4Stl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal synaptic transmission ( J:82744 )
• mutants exhibit normal basal neurotransmitter release at CA3-CA1 synapses but show an enhanced activity-dependent increase in the probability of release during repetitive presynaptic stimulation
abnormal CNS synaptic transmission ( J:82744 )
• although synaptic depression is normal, the initial facilitation of the EPSC amplitude during repetitive stimulation of synaptic inputs (frequency facilitation) is significantly enhanced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory