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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Camk2atm1Vyb
targeted mutation 1, Vadim Y Bolshakov
MGI:2655688
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Camk2atm1Vyb/Camk2atm1Vyb
Tg(Grik4-cre)G32-4Stl/0 		involves: C57BL/6 MGI:2655692


Genotype
MGI:2655692
cn1
Allelic
Composition		 Camk2atm1Vyb/Camk2atm1Vyb
Tg(Grik4-cre)G32-4Stl/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camk2atm1Vyb mutation (1 available); any Camk2a mutation (135 available)
Tg(Grik4-cre)G32-4Stl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal synaptic transmission ( J:82744 )
• mutants exhibit normal basal neurotransmitter release at CA3-CA1 synapses but show an enhanced activity-dependent increase in the probability of release during repetitive presynaptic stimulation
abnormal CNS synaptic transmission ( J:82744 )
• although synaptic depression is normal, the initial facilitation of the EPSC amplitude during repetitive stimulation of synaptic inputs (frequency facilitation) is significantly enhanced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory