Phenotypes associated with this allele

• Allele Symbol: Bdnf^{tm1(Ntf3)Pern}
• Allele Name: targeted mutation 1, Patrik Ernfors
• Allele ID: MGI:2655761
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bdnf^tm1(Ntf3)Pern/Bdnf^tm1(Ntf3)Pern	involves: 129P2/OlaHsd	MGI:2655764

Genotype
MGI:2655764

hm1

• Allelic Composition: Bdnf^{tm1(Ntf3)Pern}/Bdnf^{tm1(Ntf3)Pern}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:82462 )

• animals die between 3-4 weeks of age

behavior/neurological

impaired balance ( J:82462 )

impaired coordination ( J:82462 )

growth/size/body

abnormal fungiform papillae morphology ( J:82462 )

• loss of fungiform papillae is seen in 2 week old mutants, with only about 1/3 of the papillae remaining

• remaining papillae are smaller

increased body weight ( J:82462 )

• compared to Bdnf ^tm1Jae mice

nervous system

abnormal innervation ( J:82462 )

• ampullar cristae completely lack innervation

abnormal sensory neuron morphology ( J:82462 )

• although mutants show normal innervation throughout all turns of the cochlea and most outer hair cells, the nerve fibers appear not to branch and project spirally to the same degree as wild-type

abnormal inner ear vestibular sensory neuron innervation pattern ( J:82462 )

• innervation of the vestibular sensory epithelia is strongly reduced at P16 and P17, with afferent fibers that reach the sensory epithelia of the utricular and saccular maculae but do not show differentiation into calyces around the type I hair cells

abnormal geniculate ganglion morphology ( J:82462 )

• loss of neurons in the geniculate ganglion

small nodose ganglion ( J:82462 )

• decrease in numbers of neurons in the nodose ganglion

abnormal vestibular ganglion morphology ( J:82462 )

• in co-cultures of wild-type vestibular ganglion neurons with mutant hair cells, wild-type neurons do contact mutant hair cells as in wild-type, however the nerve fibers are thin, show little branching and do not wrap around the hair cells

vestibular ganglion degeneration ( J:82462 )

• slow gradual loss of the vestibular ganglion neurons, such that at P17 nearly half of the neurons seen at P0 are lost

digestive/alimentary system

abnormal fungiform papillae morphology ( J:82462 )

• loss of fungiform papillae is seen in 2 week old mutants, with only about 1/3 of the papillae remaining

• remaining papillae are smaller

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:82462 )

N • mutants exhibit normal auditory function and innervation of outer hair cells, unlike Bdnf ^tm1Jae mice

abnormal cochlea morphology ( J:82462 )

• although mutants show normal innervation throughout all turns of the cochlea and most outer hair cells, the nerve fibers appear not to branch and project spirally to the same degree as wild-type

abnormal crista ampullaris morphology ( J:82462 )

• ampullar cristae completely lack innervation

abnormal inner ear vestibular sensory neuron innervation pattern ( J:82462 )

• innervation of the vestibular sensory epithelia is strongly reduced at P16 and P17, with afferent fibers that reach the sensory epithelia of the utricular and saccular maculae but do not show differentiation into calyces around the type I hair cells

taste/olfaction

abnormal gustatory system morphology ( J:82462 )

• gustatory innervation is disrupted, while lingual somatosensory innervation is intact

craniofacial

abnormal fungiform papillae morphology ( J:82462 )

• loss of fungiform papillae is seen in 2 week old mutants, with only about 1/3 of the papillae remaining

• remaining papillae are smaller