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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igbp1tm1Imku
targeted mutation 1, Nobuo Sakaguchi
MGI:2656093
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Igbp1tm1Imku/Y
Tg(Igbp1b-cre)1Imku/0 		B6.Cg-Igbp1tm1Imku Tg(Igbp1b-cre)1Imku MGI:3623760
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Igbp1tm1Imku/Y 		involves: 129P2/OlaHsd MGI:3603798
cn3
 		Igbp1tm1Imku/Y
Tg(Lck-cre)I57Jxm/? 		involves: 129P2/OlaHsd * ICR MGI:3603799


Genotype
MGI:3623760
cn1
Allelic
Composition		 Igbp1tm1Imku/Y
Tg(Igbp1b-cre)1Imku/0
Genetic
Background		 B6.Cg-Igbp1tm1Imku Tg(Igbp1b-cre)1Imku
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igbp1tm1Imku mutation (0 available); any Igbp1 mutation (9 available)
Tg(Igbp1b-cre)1Imku mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal cued conditioning behavior ( J:107484 )
• prolonged response latency compared to control mice
abnormal spatial learning ( J:107484 )
• in probe trials using a Morris water maze, mutant mice spend less time in the quadrant where the hidden platform had been located

nervous system
nervous system phenotype ( J:107484 )
N
• brain morphology is similar to control mice




Genotype
MGI:3603798
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Igbp1tm1Imku/Y
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Igbp1tm1Imku mutation (0 available); any Igbp1 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:74619 )
• no somatic hypermutation takes place
decreased B cell number ( J:74619 )
• decreased B220+ cells but cells have a normal maturation phenotype
• decreased numbers involve IgM+ IgDhi
decreased follicular B cell number ( J:74619 )
• CD23+IgM+ follicular cells in the spleen were reduced as were CD40+ cells
decreased pre-B cell number ( J:74619 )
• reduced in numbers although normal numbers of pro B cells are present in bone marrow
abnormal spleen germinal center morphology ( J:74619 )
• germinal center formation is impaired
decreased B cell proliferation ( J:74619 )
• impaired proliferative responses, failure of G1/S transition
decreased immunoglobulin level ( J:74619 )
• stimulated antibody production is low
• T cell dependent antibody production more affected than T cell independent production

hematopoietic system
abnormal somatic hypermutation frequency ( J:74619 )
• no somatic hypermutation takes place
decreased B cell number ( J:74619 )
• decreased B220+ cells but cells have a normal maturation phenotype
• decreased numbers involve IgM+ IgDhi
decreased follicular B cell number ( J:74619 )
• CD23+IgM+ follicular cells in the spleen were reduced as were CD40+ cells
decreased pre-B cell number ( J:74619 )
• reduced in numbers although normal numbers of pro B cells are present in bone marrow
abnormal spleen germinal center morphology ( J:74619 )
• germinal center formation is impaired
decreased B cell proliferation ( J:74619 )
• impaired proliferative responses, failure of G1/S transition
decreased immunoglobulin level ( J:74619 )
• stimulated antibody production is low
• T cell dependent antibody production more affected than T cell independent production

cellular
decreased B cell proliferation ( J:74619 )
• impaired proliferative responses, failure of G1/S transition




Genotype
MGI:3603799
cn3
Allelic
Composition		 Igbp1tm1Imku/Y
Tg(Lck-cre)I57Jxm/?
Genetic
Background		 involves: 129P2/OlaHsd * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igbp1tm1Imku mutation (0 available); any Igbp1 mutation (9 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal thymus cortex morphology ( J:84395 )
• largely lacking in double positive cells
abnormal thymus corticomedullary boundary morphology ( J:84395 )
• demarcation between cortex and medulla indistinct
decreased T cell number ( J:84395 )
• peripheral spleen T cells 30% of control levels
decreased thymocyte number ( J:84395 )
• thymocyte production only 4.3% normal
• few proliferating thymocytes
decreased double-negative T cell number ( J:84395 )
• double negative cells are proportionately higher but absolute numbers are reduced
• development blocked at DN3 stage

hematopoietic system
abnormal thymus cortex morphology ( J:84395 )
• largely lacking in double positive cells
abnormal thymus corticomedullary boundary morphology ( J:84395 )
• demarcation between cortex and medulla indistinct
decreased T cell number ( J:84395 )
• peripheral spleen T cells 30% of control levels
decreased thymocyte number ( J:84395 )
• thymocyte production only 4.3% normal
• few proliferating thymocytes
decreased double-negative T cell number ( J:84395 )
• double negative cells are proportionately higher but absolute numbers are reduced
• development blocked at DN3 stage

endocrine/exocrine glands
abnormal thymus cortex morphology ( J:84395 )
• largely lacking in double positive cells
abnormal thymus corticomedullary boundary morphology ( J:84395 )
• demarcation between cortex and medulla indistinct
decreased thymocyte number ( J:84395 )
• thymocyte production only 4.3% normal
• few proliferating thymocytes




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory