Phenotypes associated with this allele

• Allele Symbol: Pdgfra^tm6Sor
• Allele Name: targeted mutation 6, Philippe Soriano
• Allele ID: MGI:2656147
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfra^tm6Sor/Pdgfra^tm6Sor	either: 129S4/SvJaeSor-Pdgfra^tm6Sor or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:3694472
ht2	Pdgfra^tm6Sor/Pdgfra^tm11(EGFP)Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:3694484

Genotype
MGI:3694472

hm1

• Allelic Composition: Pdgfra^tm6Sor/Pdgfra^tm6Sor
• Genetic Background: either: 129S4/SvJaeSor-Pdgfra^tm6Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:73817 )

• 60% die by P35, although a few survive for over 12 months

nervous system

seizures ( J:73817 )

• Background Sensitivity: exhibit spontaneous seizures that are more severe on a mixed 129S4/SvJaeSor and C57BL/6J background than on a coisogenic 129S4/SvJaeSor background

abnormal myelination ( J:73817 )

• most regions of the CNS displays severe hypomyelination

behavior/neurological

tremors ( J:73817 )

• Background Sensitivity: exhibit shaking; phenotype is more severe on a mixed 129S4/SvJaeSor and C57BL/6J background than on a coisogenic 129S4/SvJaeSor background

abnormal locomotor coordination ( J:73817 )

• decrease in limb mobility

seizures ( J:73817 )

• Background Sensitivity: exhibit spontaneous seizures that are more severe on a mixed 129S4/SvJaeSor and C57BL/6J background than on a coisogenic 129S4/SvJaeSor background

skeleton

skeleton phenotype ( J:73817 )

N • do not exhibit skeletal defects

craniofacial

craniofacial phenotype ( J:73817 )

N • do not exhibit cleft palate

Genotype
MGI:3694484

ht2

• Allelic Composition: Pdgfra^tm6Sor/Pdgfra^{tm11(EGFP)Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

nervous system

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

abnormal oligodendrocyte morphology ( J:73817 )

• oligodendrocyte progenitor cell (OPC) migration away from their point of origin in the ventricular zone is inhibited between E12.5 and E13.5; although some OPCs eventually migrate out from the ventricular zone, they fail to evenly populate the spinal cord by the end of embryogenesis when myelination begins

cellular

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis