Analysis Tools
nervous system
| N |
• homozygotes exhibit a nearly normal brain size, shape and weight, with no detectable histological alterations in the cortex, striatum, callosum, hippocampus, ventricles, choroid plexus, cerebellum, and brain stem
• no abnormalities in laminar architecture or number of neurons are detected in the retina
|
|
• at 10 wks after resection of the hypoglossal nerve, homozygotes show a ~45% reduction in nerve regeneration along with a ~50% decrease in the number of surviving neurons relative to wild-type mice, indicating impaired repair of damaged hypoglossal nerves
|
immune system
| N |
• homozygotes exhibit no detectable differences in thymus or spleen size, shape, and cellularity relative to wild-type littermates
• mutant thymocytes display normal sensitivity to Fas-mediated apoptosis induced by Jo2 (1-1,000 ng/ml) in the presence of cycloheximide
|
|
• homozygotes show a general increase in the proliferative response to various stimuli (concanavalin A, anti-CD3) relative to wild-type mice
|
hematopoietic system
|
• homozygotes show a general increase in the proliferative response to various stimuli (concanavalin A, anti-CD3) relative to wild-type mice
|
behavior/neurological
| N |
• homozygotes are behaviorally normal with no signs of ataxia and no significant differences in hindlimb reflex, posture, spontaneous motor activity, swimming ability, and flinch hearing relative to wild-type control mice
• homozygotes exhibit no memory or learning deficits as determined by the Morris water-maze test, passive avoidance test, and Y-maze test
|
cellular
|
• homozygotes show a general increase in the proliferative response to various stimuli (concanavalin A, anti-CD3) relative to wild-type mice
|
