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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ntrk3tm1Kln
targeted mutation 1, Rudiger Klein
MGI:2656335
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ntrk3tm1Kln/Ntrk3tm1Kln involves: 129P2/OlaHsd * C57BL/6 MGI:2656375
cx2
 		Ntrk2tm1Kln/Ntrk2tm1Kln
Ntrk3tm1Kln/Ntrk3tm1Kln 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2656338


Genotype
MGI:2656375
hm1
Allelic
Composition		 Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk3tm1Kln mutation (0 available); any Ntrk3 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased sensory neuron number ( J:75365 )
• 25% reduction in number of cochlear neurons
abnormal cochlear nerve morphology ( J:75365 )
• 25% reduction in number of cochlear neurons, however target innervation by cochlear neurons is normal




Genotype
MGI:2656338
cx2
Allelic
Composition		 Ntrk2tm1Kln/Ntrk2tm1Kln
Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1Kln mutation (0 available); any Ntrk2 mutation (66 available)
Ntrk3tm1Kln mutation (0 available); any Ntrk3 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased sensory neuron number ( J:75365 )
• 56% reduction of cochlear neurons at P70
abnormal cochlear nerve morphology ( J:75365 )
• 56% reduction in number of cochlear neurons at P70, however target innervation of the remaining cochlear neurons and hearing are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory